Genomic Imprinting-refers to an epigenetic marking of genes that results to monoallelic expression. It is involved in fetal and behavioral development.
by VeoLega 10
1. Two clinically distinct genetic disease with genomic imprinting on chromosome 15q11-q13
2. Angel Syndrome-associated with deletion of the longarm of chromosome 15 inherited from the mother
3. Prader Willi Syndrome-associated with deletion of the longarm of chromosome 15 inherited from the father.
4. features and diagnostic criteria include short stature, hypotonia, small hands and feet, obesity, mild to moderate mental retardation, and hypogonadism
5. Features and diagnostic criteria includes severe mental retardation,seizures, and an ataxic gait
6. Prader Willi and Angelman Syndrome are autosomal dominant disorder displaying parent-of origin effect since the inherited diseases are transmitted from only one of the parents
7. Treatments for Prader Willi syndrome depend of the individual's symptom which includes use of special nipples for feeding difficulties,strict supervision of daily food intake,growth hormone therapy,physical therapy,behavioral therapy,medications like serotonin reuptake inhibitors, early interventions as Prader Willi Syndrome has varying degrees of intellectual disabilities
8. There is no specific therapy for Angelman Syndrome.Medical therapy for seizures are usually necessary. Physical,occupational,behavioral therapy is important in allowing an individual to function to their maximum potential in the community.
