Cannabinoid system
von Bonnie Humphrey
1. Exogenous cannabinoids
1.1. THC
1.1.1. Synthetic, hydrophilic analogue of THC: [3H]CP-55,940
1.1.2. Synthetic cannabinoid: HU-210 800x more potent than THC
1.2. CBD
2. Ways to detect ECS
2.1. Ligand assay
2.2. Behaviour assay
2.3. Genetic profiling
3. Cannabinoid signalling system
3.1. G protein coupled receptors
3.1.1. CB1 - in Brain cells
3.1.1.1. Antagonist "a substance which interferes with or inhibits the physiological action of another"
3.1.1.1.1. CB1 antagonist: SR141716A
3.1.2. CB2 - in Immune cells
3.1.2.1. CB2 antagonist: SR144528
4. Endogenous CB system
4.1. Receptors
4.2. Endogenous cannabiniods
4.2.1. Ligand 1: Anandamide
4.2.1.1. Hydrolyzed by FAAH
4.2.2. Ligand 2: 2-arachidonylglycerol