Antihypertensives: THIAZIDE

1. indicated: M//c for mild to moderate HTN- First line

2. AE: electrolyte imbalances; hypokalemia, hyponatremia, hypoMg; hyper calcemia (where thiazides work in kidney they preserve Ca from being excreted; muscle cramps, dizzy, sexual dysfunction, hyperlipidemia and hyper uricemia

3. interactions/CI: NSAIDS-blunt effects fo antiHTNs; quinidine and digitalis(increased arrhythmias); not useful in renal failure w/o adequate output

4. hydrocholorothiazide (HCTZ)

4.1. seen in combo drugs: inexpensive

5. chlorthalidone

5.1. M/C used; longer duration of action and clinical trials better

6. metolazone

7. indapamide

7.1. longer duration of action and clinical trials better

8. MOA: inhibit NaCl and H2O reabsorption from DCT by blocking Na/Cl transport channel; may have direct vascular smooth muscle relaxing abilities; K and H20 and NaCl stay in filtrate when you block transport channel