1. Complications
1.1. Lack of Quality Sleep
1.2. Ecomonic Setback
1.3. Relationships
1.4. Suicide
2. Comorbidities
2.1. Body Systems
2.2. Epilepsy
2.3. Migraine Related Strokes
3. Diagnosis
3.1. International Headache Society Criteria
3.1.1. Attacks
3.1.2. Two of Four
3.1.3. One
3.2. Medical History and Physical Exam
3.3. Imaging Not Necessary
3.3.1. Differential Diagnosis
4. Treatment
4.1. Referrals
4.2. Prophylactic
4.2.1. Patient Education
4.2.2. Diet
4.2.2.1. Caffeine
4.2.2.2. Ketogenic or Atkins Diet
4.2.3. Rx
4.2.3.1. Antiepileptics
4.2.3.2. Antidepressants
4.2.3.3. Antihypertensives
4.2.3.4. Other
4.2.3.5. Monoclonal Antibody
4.3. Mild
4.3.1. APAP
4.3.2. NSAID
4.3.3. Antiemetic
4.3.4. Neuroleptic
4.4. Moderate-Severe
4.4.1. Triptan
4.4.2. Gepants
5. Etiology
6. Pathophysiology
6.1. No Identifiable Pathophysiology
6.2. Trigeminovascular Activation
6.2.1. TTNs
6.2.2. Nuerovascular Inflammation
6.2.2.1. Cortical Spreading Depression
6.2.2.2. Altered Cytokines
6.2.2.2.1. Increased Pro-Inflammatory Cytokines
6.2.2.2.2. Decreased Anti-Infalmmatory Cytokines
6.2.2.3. Hormones
6.2.2.3.1. Female Population
6.2.2.3.2. Other
6.2.2.3.3. Serotonin and Dopamine
6.3. Secondary to Genetics and Environment
6.3.1. Genetics
6.3.1.1. Mutations
6.3.1.1.1. CACNA1A, ATP1A2, SCN1A
6.3.1.2. Familial Hemiplagic
6.3.2. Environment
7. Most Common Triggers
8. Risks
8.1. Fatigue
8.2. Dietary
8.3. Metabolic and other Disorders
8.4. Psychological
8.4.1. Personality