1. HISTOLOGY
1.1. segmental necrosis
1.2. fibrin deposition
2. STEPS
2.1. 1. immune complex formation
2.2. 2. immune complex deposition
2.3. 3. inflammation
3. SYMPTOMS
3.1. SKIN
3.1.1. Palpable purpura
3.1.2. RBC extravasation by immune complexes
3.1.3. common in legs- gravity dependent areas
3.2. LUNGS
3.2.1. pulmonary infiltrates
3.2.2. sinusitis/epistaxis
3.3. KIDNEY
3.3.1. urinary sediment
3.3.2. GN
3.3.3. HTN
3.4. NEUROLOGIC
3.4.1. foot drop
3.4.2. mononeuritis complex
3.5. SYSTEMIC
3.5.1. fever, sweats, weight loss
3.6. MUSCULOSKELETAL
3.6.1. arthralgia
3.6.2. muscle pain/claudication
3.7. GI
3.7.1. abdominal pain
3.7.2. bloody stools
4. What is it?
4.1. BV inflammation
4.1.1. vessel occlusion
4.1.2. tissue ischemia
4.1.3. necrosis
5. CLASSIFICATION
5.1. vessel size
5.1.1. large
5.1.1.1. giant cell arteritis
5.1.1.2. Takayasu's arteritis
5.1.2. medium
5.1.2.1. polyarteritis nodosa
5.1.2.2. kawasaki's disease
5.1.2.3. Buerger's disease
5.1.3. small
5.1.3.1. Wegener's Granulomatosis
5.1.3.2. Microscopic Polyangitis
5.1.3.3. Churg Strauss
5.1.3.4. Henoch Schonlein Purpura
5.2. pathogenesis
5.2.1. infectious
5.2.2. immunologic rxn
5.2.3. radiation
5.3. anatomic site
5.4. distribution
5.4.1. localized
5.4.2. systemic
5.5. duration
5.5.1. acute
5.5.2. chronic