Lymphoma

1. malignant neoplasm of lypmphocytes

2. Location & extent of Dx affects staging Tx & prognosis

3. presents with enlarged, painless mobile lymph nodes of the neck

4. Most common head/neck region for extranodal lymphoma in Waldeyer's ring:

4.1. tonsils

4.2. nasopharyns

4.3. base of tongue region

5. Hodgkin's

5.1. 15% of lymphomas

5.2. poss. origination in B-lymphocytes

5.3. Disease process of lymph nodes only

5.4. REED-STERNBERG cells are histopathological findings

5.5. Ave. onset=27y/o

6. Non-Hodgkin's

6.1. 85% of all lymphomas

6.2. Poss. origination of B & T lymphocytes

6.3. usually presents as disease process of extranodal & lymph nodes

6.4. Ave. onset=67y/o

7. Ann Arbor Staging Classification for both Hodgkin's & Non-Hodgkin's

7.1. Stage I: single lymph node region

7.2. Stage II: 2 or more regions

7.3. Stage III: both sides of diaphragm

7.4. Stage IV: diffuse

7.5. A-Absence of systemic symptoms

7.6. B-Presence of systemic symptoms

7.7. C-Localized extranodal extension

7.8. S-Splenic involvement

8. MOST COMMON primary malignancy that occurs in the head and neck region 2nd to SCC

9. other sites:

9.1. paranasal sinus

9.2. nasal cavity

9.3. larynx

9.4. oral cavity

9.5. parotid gland

9.6. thyroid

10. Work-up:

10.1. FNA

10.2. open biopsy if FNA tissue is insufficinet

11. Staging Work-up:

11.1. Labs

11.2. CXR to r/o mediastinal involvement

11.3. CT head/neck w/&w/o contrast

11.4. MRI chest/abd/pelvis

11.5. Bone marrow biopsy