Process of Hemostasis & its Aftermath
par Sujoy Bose
1. Where is factor VI?
1.1. Factor VI is referred to as "Unassigned" due to being found to be part of another factor
2. Coagulation Factors
2.1. I
2.2. II
2.3. III
2.4. IV
2.5. V
2.6. VII
2.7. VIII
2.8. IX
2.9. X
2.10. XI
2.11. XII
3. Platelet
4. Tissue Plasminogen Activator (tPA)
4.1. Converts Plasminogen to Plasmin
4.1.1. Fibrinogen to FDPs
4.1.2. Fibrin to FDPs
5. 2. Primary Hemostasis
5.1. Tests
5.1.1. PT (WR)
5.1.1.1. Tests the Extrinsic Pathway
5.1.2. aPTT (HEP)
5.1.2.1. Tests the Intrinsic Pathway
5.2. End-Result: Temporary Platelet Plug
5.3. Tests
5.3.1. Platelet Count (PC)
5.3.2. Bleeding Time (BT)
5.4. Disorder Symptoms of Primary Hemostasis (Superficial Bleeding)
5.4.1. Muco
5.4.1.1. Epistaxis
5.4.1.2. Menorrhagia
5.4.1.3. Easy Bruising
5.4.1.4. Gum (Gingival) bleeding
5.4.2. Cutaneous
5.4.2.1. Petechiae
5.4.2.2. Purpura
5.4.2.3. Ecchymosis
6. 3. Secondary Hemostasis
6.1. End-Result: Fibrin Thrombus that Contracts & Serum expressed (Strengthens the Clot)
6.2. Symptoms of Disorders
6.2.1. Joints
6.2.1.1. Hemarthrosis
6.2.2. Muscles
6.2.2.1. Muscle hematoma
6.2.3. Brain
6.2.3.1. Hemorrhage
6.2.4. Late rebleeding
6.2.5. Bleeding after tooth extraction
7. 4. Fibrinolysis
7.1. Dissolves the Clot & Restores the function
7.2. Tests
7.2.1. Fibrin Degradation Products (FDPs)
7.2.1.1. D-dimer