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1. ENDOTHELIAL ACTIVATION

1.1. CELL JUNCTION

1.2. ADHESION MOLECULES

1.3. CONTRACTION

1.4. RELEASE OF MEDIATORS

2. CLASSIFICATION

2.1. TEMPORAL FEATURES

2.1.1. ACUTE

2.1.1.1. COMPONENTS

2.1.1.1.1. Usually sequece of

2.1.1.2. SYMPTOMS & SIGNS

2.1.1.2.1. Local symptomatology (CADINAL SIGNS)

2.1.1.2.2. Systemic symptomatology (ACUTE PHASE REACTION)

2.1.1.3. OUTCOMES

2.1.1.3.1. ELIMINATION

2.1.1.3.2. CHRONICITY

2.1.2. CHRONIC

2.1.2.1. COMPONENTS

2.1.2.1.1. Concomittant presence of

2.1.2.2. SYSTEMIC SIGNS & SYMPTOMS

2.1.2.2.1. SUBFEBRILITY

2.1.2.2.2. WEIGHT LOSS

2.1.2.2.3. ANEMIA

2.2. PREDOMINANT PROCESS/ MORPHOLOGIC PATTERN

2.2.1. ALTERATIVE -> necrosis

2.2.1.1. TYPICAL CAUSED BY TOXINS, ENZYMES, VIRUSES - non-specific nectotising lesions

2.2.1.2. GANGRENOUS

2.2.1.2.1. TYPES

2.2.1.2.2. COMPLICATIONS

2.2.2. EXUDATIVE -> exudate

2.2.2.1. ROLE

2.2.2.1.1. DILUTION OF HARMFUL AGENTS

2.2.2.1.2. DELIVERY OF CELLS AND MEDIATORS

2.2.2.2. TYPES

2.2.2.2.1. SEROUS

2.2.2.2.2. FIBRINOUS

2.2.2.2.3. SUPPURATIVE/PURULENT

2.2.2.2.4. HAEMORRHAGIC

2.2.2.2.5. COMBINATIONS -> VERY COMMON

2.2.3. PROLIFERATIVE -> proliferation

2.2.3.1. REACTIVE PROLIFERATION OF TISSUE CELLS

2.2.3.2. REACTIVE PROLIFERATION OF INFLAMMATORY CELLS

2.2.3.3. GRANULATION TISSUE-> SCARRING

2.2.3.4. GRANULOMATOUS INFLAMMATION

2.2.3.4.1. FORMATION OF GRANULOMAS

2.3. HISTOLOGICAL FEATURES

2.3.1. NON-SPECIFIC

2.3.2. SPECIFIC

2.4. CAUSATIVE AGENT

2.4.1. ASEPTIC

2.4.2. SEPTIC

3. GENERAL FEATURES

3.1. RESPONSE OF TISSUES TO INJURY/INFECTION

3.2. GOAL

3.2.1. ELIMINATE/SEPARATE NOXIOUS AGENTS

3.2.2. REMOVE NECROTIC TISSUE & INITIATE REPAIR

3.3. COURSE AND MORPHOLOGY DEPENDS ON

3.3.1. INJOURIOUS FACTOR

3.3.2. EXTENT OF DAMAGE

3.3.3. LOCATION/MICROENVIRONMENT

3.4. PHASES

3.4.1. INITIATION

3.4.1.1. pathogen/dead tissue components (PAMP/DAMP) recognized by patter recognition receptors (PRRs)

3.4.2. ACCELERATION

3.4.2.1. release of mediators and cell recruitment

3.4.3. ELIMINATION

3.4.4. TERMINATION

4. CELLS & MEDIATORS

4.1. MEDIATORS (Robbins, 9th ed)

4.1.1. cytokines

4.1.2. Reactive oxygen species/ROS

4.1.2.1. ROS generation

4.1.3. complement

4.1.3.1. complement

4.1.3.1.1. complement

4.2. INFLAMMATORY CELLS

4.2.1. -

4.2.1.1. -

4.2.1.1.1. -

5. DEFECTS OF CELLULAR RESPONSE

5.1. LEUCOCYTE ADHESION DEFICIENCY (LAD) (β2-integrin (type 1), selectin (type2))

5.2. BRUTON'S AGAMMAGLOBULINEMIA (opsonisation)

5.3. CHEDIAK-HIGASHI (phagolysosome)

5.4. CHRONIC GRANULOMATOUS DISEASE (O2-DEPENDENT MPO SYSTEM)

6. FREQUENTLY CONFUSED TERMS