The Impact of Gene Therapy
por Liu Chinhong
1. 3. Drop in blood pressure
2. Gene-editing system and cell types
2.1. CRISPR
2.1.1. An immune system found in bacteria and modified in human
2.2. Somatic Cell Gene Therapy (SCGT)
2.2.1. Germ cells and stem cells (Non-heritable)
2.3. Germline Gene Therapy (GGT)
2.3.1. Egg cells and sperm (Heritable)
3. Benefits
3.1. 1. Prevent genes defect
3.2. 2. The ability to edit live cells
3.3. 3. Treat cancer, genetic diseases
3.3.1. Color blindness
3.3.2. Hemophilia
3.3.3. Cystic fibrosis
3.3.4. Down syndrome
4. Problems
4.1. 1.Off-target mutations
4.2. 2. Infection by virus
4.3. 3. Unfavorable symptoms due to foreign vector
4.3.1. 1. fever
4.3.2. 2. Rigors
4.3.3. 4. Nausea
4.4. 4. Costs problems
4.4.1. Research: Gene therapy: evidence, value and affordability in the US health care system Journal: Future medicine Year: 2017 volume: 14 Pages: 16-21
5. Origin
5.1. Human genome project launched in the US in the 1990s
5.1.1. Article: History of gene therapy journal: Gene Year:2013 Volume 525, Issue 2, 10 Pages 162-169
5.2. Genome editing in humans by Chinese scientist He Jiankui in 2018
6. Procedures
6.1. 1. Creating working gene
6.2. 2. Building therapeutic vector
6.3. 3. Determining eligibility
6.4. 4. Delivering gene
6.5. 5. Monitoring safety and efficacy
7. Science involved
7.1. 1. Biology
7.1.1. Cell manipulation
7.1.2. Immunology
7.2. 2. Biotechnology
7.2.1. DNA testing