CHEMO; hormones

1. GnRH releasing analogs

1.1. MOA: GnRH analogs initially stimulate then inhibit FSH and LH = decrease estrogen and testosterone

1.2. leuprolide; goserelin

1.3. for prostate and metastatic breast cancer

1.4. AE: hot flashes; decreased bone mass; libido decline

2. Antiestrogens

2.1. MOA: selective estrogen receptor (ER) modulators/downregulates expression

2.2. Tamoxifen; fulvestrant

2.3. ER positive breast cancer tx and prevention in high risk pts

2.4. AE: hot flashes; n/v; monitor for endometrial cancer

3. antiandrogens

3.1. useful in prostate cancer

4. Aromatase inhibitors

4.1. MOA: inhibit aromatase = less estrogen

4.2. Anastrozole; Letrozole

4.3. for Breast cancer

4.4. AE: well tolerated