WBC/RBC Disorders

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WBC/RBC Disorders by Mind Map: WBC/RBC Disorders

1. Eosinophilic Granuloma (Benign; pathologic fractures; increased LC in bone)

2. Folate Deficiency

3. Hemoglobin C

4. Bone Marrow

4.1. CD34+ Hematopoietic Stem Cell

4.1.1. Myeloid Stem Cell Blasts (Delicate chromatin, increased cytoplasm). Acute Myelogenous Leukemia (AML) [MPO+ --> Auer Rods (Condensed azurophilic granules --> DIC) , > 20% blasts] Myelodysplastic Syndrome Mature Myeloproliferative Disorders Langerhans Cell Histiocytes (Derived from Monocytes) Langerhans Cells (in skin; CD1a+, S100+; tennis racket (Birbeck granules) Types RBC Disorders Anemia

4.1.2. Lymphoid Stem Cell Blasts Acute Lymphoblastic Leukemia (ALL) Mature Chronic Lymphocytic Leukemia (CLL) Plasma Cell Disorders (Dyscrasias) Multiple Myeloma Waldenstrom Macroglobinemia ( B Cell lymphoma w/ monoclonal IgM)

5. Lymph Nodes

5.1. Lymphadenopathy

5.1.1. Painful when draining acute infection (Acute lymphadenitis) & Painless with chronic inflammation

5.1.2. Folicular Hyperplasia (B-Cell) in rheumatoid, early HIV

5.1.3. Paracortex (Viral)

5.1.4. Sinus Histiocytes in Medulla (Cancer)

5.2. Lymphoma

5.2.1. Non-Hodgkin Types Small Cell Intermediate Cell Large Cell 60% of Lymphomas; CD20+

5.2.2. Hodgkin Types Nodular Sclerosis (Most common forms, RS in Lacunar Cells) Lymphocyte-rich (best prognosis) Lymphocyte-depleted (worst prognosis) Mixed Cellularity Reed-Sternberg Cells; CD15, CD30; Multi-lobed B Cells