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V. Homberg, Germany - Neuro rehabilitation by Mind Map: V. Homberg, Germany - Neuro rehabilitation
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V. Homberg, Germany - Neuro rehabilitation

"Training Techniques"

Neurophysiological basis?

In short: no...

Evidence based medicine

some historical background on topic

George Fordyce

James Lind, first clinical trial

Pierra C A Louis

Ignaz Semmelweis

David Sackett

Archie Cochrane, RCTs and critical summaries

Quality of study is the extent to which its design excludes bias

Nothing improves the performance of an intervention as much as the absence of a comparison group

Levels & Types of Evidence

Evidence based practice and the real world (after Davidoff)

Motor recovery after stroke: a systematic review


Link to paper

Meeting notes by

Paul de Roos

Mindmap hosted on, Twitter:,


Controversies in Neurology, Linkt to website

Meeting Overview mindmap, Link to mindmap

The Pros

High statistical reliability (esp in avoiding type I errors)

Power to compile results from multiple RCT (meta analysis)

Educates to be critical about claims of effectiveness


multiple evidence based therapy options available

The cons

Many more

Is there a way out of this dilemma?

the results form RCTs and MAs in the framework of EbM should be carefully interpreted

To avoid Type II errors believe more in positive than negative results of MAs

try to derive elementary rules from basic science

apply such elementary rules to invent therapeutic interventions

Rephrasing the epistemiological problem:

how can knowledge from relevant (basic) science help us

Rules from principles of motor learning



knowledge of results