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1. Immune system-body's natural defense system

1.1. Various cells, tissues, organs

1.2. Work collectively

1.3. Against harmful pathogens,cells and substances

2. Components

2.1. Cardiovascular

2.1.1. Heart, blood vesseld

2.2. Mononuclear phagocyte system

2.2.1. Reticular fibres network

2.2.2. Exp: macrohages

2.3. Lymphatic system

2.3.1. Lymphoid organs Primary Production sites Maturation sites (w/o antigen) Exp: bone marrow, thymus Secondary Maturation sites (with antigen) Differentiate into mature antigen-specific effector cells Exp: adenoid, tonsils, lymph nodes, spleen, MALT

3. Cells

3.1. Leukocytes

3.1.1. Have nuclei

3.1.2. Phagocytosis, inflammation. daptive immune response

3.1.3. Types Basophils Inflammation Neutrophils Phagocytic properties Eosinophils Parasitic infections, allergic Monocyte Precursor for macrophages Lymphocytes B-cells and T-cells Mast cells 'master regulators' Natural killer (NK) cells cytotoxic- contain special protein (granzymes) Tumor and viral infection

3.2. Platelets

3.2.1. No nuclei

3.2.2. Inflammation, blood clotting

4. Innate immunity

4.1. Non-specific

4.2. Preformed

4.3. Similar response magnitude (first and subsequent infections

4.4. No memory stored

4.5. Examples

4.5.1. First line defence Physical barriers Saliva, tears, skin, mucus, stomach acid, bacteria gut

4.5.2. Second line defence Physiological barriers - hostile environment Components Fever Inflammation Phagocytosis Antimicrobial proteins