cell injury: cellular accumulations

1. protein

1.1. beta lymphcytes

1.1.1. Leukemia?

1.2. kidney

1.2.1. convoluted tubule

1.3. emphyzema

1.3.1. slow protein folding

1.4. Alzheimer

1.4.1. cytoskeletal

2. pigments

2.1. melanin

2.1.1. melanoma

2.2. hemosiderosis

2.2.1. iron overload

2.2.1.1. ferritin 60 - 80 g

2.3. bilirubin

2.3.1. jaundice

2.3.1.1. >1.5 mg/dL

3. urate

3.1. uric acid

3.2. gout

4. water

4.1. swelling

4.1.1. oncosis

4.1.1.1. ISCHEMIC cell death

4.1.1.1.1. Starts w/membrane permeability

4.2. causes

4.2.1. insufficient removal

4.2.1.1. abnormal metabolism

4.2.2. protein folding

4.2.2.1. mutation

4.2.3. ingestion

4.2.3.1. undigestible

4.2.4. lack enzyme storage ??

4.2.5. exogenous material accumulation

5. lipids

5.1. big greasy organs

5.2. most affected

5.2.1. spleen

5.2.2. liver

5.2.3. CNS

6. carbohydrates

6.1. examples

6.1.1. Tay Sachs

6.1.2. fatty liver (both)

6.2. glycogen

6.2.1. excessive vacuolation

6.2.2. genetic

6.2.3. diabetes

7. calcium

7.1. dystrophic calcification

7.1.1. areas of necrosis

7.2. psammoma bodies

7.2.1. center of tumors

7.3. metabolic calcification