ANTIPSYCHOTIC DRUG

1. ATYPICAL

1.1. Example

1.1.1. Clozapine

1.1.2. Olanzapine

1.1.3. Quetiapine

1.2. MOA

1.2.1. Serotonin 2A/D2 dopamine antagonism

1.3. Side effect

1.3.1. Sedation

1.3.2. Weight gain

1.3.3. Diabetes Mellitus

2. TYPICAL

2.1. Example

2.1.1. Chlorpromazine

2.1.2. Haloperidol

2.1.3. Perphenazine

2.2. MOA

2.2.1. D2 antagonist

2.3. Side effect

2.3.1. Cognitive toxicity

2.3.2. Extrapyramidal symptoms

2.3.3. Sedation

3. acts on

3.1. Mesolimbic

3.1.1. Regulate positive symptoms of psychosis

3.2. Mesocorticol

3.2.1. Involve in the negative and cognitive symptoms of Schizophrenia

3.3. Nigrostriatal

3.3.1. Regulate extrapyramidal nervous system and movement

3.4. Tuberoinfundibular

3.4.1. Regulate prolactin secretion