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Overview of Quinolones by Mind Map: Overview of Quinolones
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Overview of Quinolones

General information

Synthetic antimicrobial agents

First quinolone was nalidixic acid

was a bye product of chloroquine synthesis

Used traditionally for UTI

Addition of fluoride made a new class (fluroquinolones)

Mechanism of action

Gm -ve

Gm +ve

Pharmacokinetics

Long half-life of new fluoroquinolones

absorption and distribution

Elimination

Classification

First generation

Nalidixic acid

Second generation

NorfloxacinLomefloxacinCiprofloxacinOfloxacin

Third generation

LevofloxacinSparfloxacinMoxifloxacin

Fourth generation

Trovofloxacin

Therapeutic use

UTIs

STDs

GI & abdominal infections

Respiratory tract infections

Bone, joint & soft tissue infections

Other infections

Adverse effects

common

hypo/hyperglycemia with gatifloxacin in old people

contraindications