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Gonadotropin, GnRH and GnRH Analogs by Mind Map: Gonadotropin, GnRH and GnRH
Analogs
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Gonadotropin, GnRH and GnRH Analogs

Luteinizing H

MOA

Female:, Stimulates ovulation, Luteinization of follicle, Synthesis and secretion of progesterone and estrogen from corpus luteum

Male, Teste: Stimulates secretion of androgens from interstitial Leydig cells

Names

Menotropins, combo of LH and FSH

Chorionic Gn

rh-lutropin alpha

Admin

IM (peptide H)

Use

Stimultes ovulation, Used in assisted pregnancy procedures

Increases fertility in men, Use testosterone to develop 2nd sexual characteristics

Kits used to predict time of ovulation

SE

Induction of multiple pregnancies (OHS), OHS can also cause ascites, shock, pulm edema, etc

FSH

Name

rh-FSH

Follitropin

Urinary FSH

Urofollitropin

MOA

Activates Gs

Ovary: promote follicle development

Testis: Stimulate testicular growth and maintain seminiferous tubule

Use

Promote ovulation

SE

OHS, multiple pregnancies

Chorionic Gn (hCG)

Not a pituitary H

synthesized by syncytiotrophoblasts in placenta, Similar structure and action as LH

Names

rh-HCG

choriogonadotropin alpha

MOA

Stimulate and sustain fn of corpus luteum

Use

induction of ovulation

descent of testes in cryptochidism

detection of pregnancy (used in preg tests)

re-start testosterone synthesis after using anabolic steroids

GnRH

Natural Gn

Gonadarelin, Only used diagnostically today

Long-acting analogs

Leuprolide

Nafareline

Admin

Leuprolide - intranasal spray

Nafareline - injection

MOA

Long-term effect: Decreased production of GnRH, Decreased estrodiol and testosterone release

Short term will see a "flair" in GnRH, LH, and FSH levels, Can be painful, If can't tolerate, use GnRH antagonist instead

Use

Tx of PMS

Endomestriosis

Prostate cancer

Central precocious puberty

Experimental use as male controceptive

GnRH antagonists

Names

Ganorelix

Centrorelix

Degarelix

Abarelix

Use

G&C: Inhibits premature LH spike prior to harvesting eggs for IVF

D&A: Tx for advanced prostate cancer

Alternate to GnRH analogs, Doesn't have the initial GnRH surge, just blocks receptor

SE

Sever allergic rxn