Schizophrenia

1. Causes

1.1. Genes

1.1.1. RGS4

1.1.2. Disc1

1.1.3. Comt

1.2. Chemical

1.3. Cellular

1.4. Enviornmental

1.4.1. Toxins

1.4.2. Familial tendencies

2. symptoms

2.1. Hallucinations

2.1.1. Auditory

2.1.2. Visiual

2.2. Delusions

2.3. Retreat from reality

2.4. Bizarre

2.4.1. aggressive

2.4.2. Clothing/Appearence

2.5. Withdrawn

2.5.1. poor eye contact

2.6. Inappropriate behaviors

2.6.1. social inattentiveness

2.6.2. unchanging facial expression

3. Treatment

3.1. Antipsychotics

3.1.1. block dopamine receptors

3.1.2. produce unwanted side effeects

3.2. 20% fail to respond

4. Drug use

4.1. Rise in serotonin

4.2. Rise in Glutumate

4.2.1. PCP

4.2.1.1. violent

4.2.1.2. disorientation

4.2.2. Ketamine

4.3. LSD

4.3.1. PCP

5. Genetics/Population

5.1. 8-10% recurrence risk with offspring of one affected parent

5.1.1. risk decreases when affected is second/third degree relative

5.1.2. increases with more affected relatives

5.2. Twins

5.2.1. higher likely hood

5.3. Genes

5.3.1. DTNBP1

5.3.2. NRG1

5.3.3. DISC1