INNATE

1. Interferons- are chemicals that coordinate the defenses against viral infections

1.1. 3 Types of Interferons

1.2. -Alpha interferons Produced by leukocytes Stimulates NK Cells -Beta interferons secreted by fibrocytes slow inflammation -Gamma interferon secreted by T cells & NK cells stimulate microphage activity

2. Physical barriers- keep hazards and materials outside of the body.

2.1. Phagocytes-cells that engulf pathogens and cell debris.

2.2. Immune surveillance- is the destruction of abnormal cells by NK cells in the peripheral tissues.

3. Fever- an elevation in body temp that accelerates tissue metabolism and defense

3.1. 37 C normal temp

4. Inflammation- is localized, tissue level response that tends to limit the spread of an injury or infection

4.1. Products of inflammation:

4.1.1. Necrosis- local tissue destruction in area of injury

4.1.2. Pus-mixture of debris and necrotic tissue

4.1.3. Abscess-pus accumulation in an enclosed space

5. Complement is a system of circulating proteins that assists antibodies in the destruction of pathogens.

5.1. Complement Activation

5.1.1. Classical Pathway-fast method C1 binds to : Antibody molecule attached to antigen

5.1.2. Alternative pathway- slow method exposed to antigen

5.1.3. Both end with conversion of inactive complement protein C3 To active form C3b

6. Immunity your born with