1.1. stroke prevention in afivb; post op hip/knee replacement VTWE prevention
1.2. rapid acting
1.3. AE: some drug interactions
1.4. CI: caution in liver pts
2. edoxaban
2.1. thromboembolism prevention in nonvalvular afib pts
3. betrixaban
3.1. rapid onset; longest half life
3.2. AE: epidural or spinal hematomas may occur in pts treated w/ betrixaban and other direct anticoags who are receiving neuraxial anesthesia or undergoing spinal puncture
4. MOA: inhibits factor Xa ->
4.1. cannot convert prothrombin into thrombin
5. rivaroxaban
5.1. prevents thrombosis after hip or knee replacement; prevention of stroke in pts w/afib; no need to monitor coag labs;
5.2. fast onset
5.3. AE: bleeding
5.4. CI: ALL factor Xa inhibitors are not to be used with mechanical heart valves -> use warfarin instead
6. reverse agent for factor Xa inhibitors (life threatening uncontrolled bleeding) = andexxa (factor Xa)
