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Lymphoma
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LB
Leslie Brown
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Lymphoma
Door
Leslie Brown
1. malignant neoplasm of lypmphocytes
2. Location & extent of Dx affects staging Tx & prognosis
3. presents with enlarged, painless mobile lymph nodes of the neck
4. Most common head/neck region for extranodal lymphoma in Waldeyer's ring:
4.1. tonsils
4.2. nasopharyns
4.3. base of tongue region
5. Hodgkin's
5.1. 15% of lymphomas
5.2. poss. origination in B-lymphocytes
5.3. Disease process of lymph nodes only
5.4. REED-STERNBERG cells are histopathological findings
5.5. Ave. onset=27y/o
6. Non-Hodgkin's
6.1. 85% of all lymphomas
6.2. Poss. origination of B & T lymphocytes
6.3. usually presents as disease process of extranodal & lymph nodes
6.4. Ave. onset=67y/o
7. Ann Arbor Staging Classification for both Hodgkin's & Non-Hodgkin's
7.1. Stage I: single lymph node region
7.2. Stage II: 2 or more regions
7.3. Stage III: both sides of diaphragm
7.4. Stage IV: diffuse
7.5. A-Absence of systemic symptoms
7.6. B-Presence of systemic symptoms
7.7. C-Localized extranodal extension
7.8. S-Splenic involvement
8. MOST COMMON primary malignancy that occurs in the head and neck region 2nd to SCC
9. other sites:
9.1. paranasal sinus
9.2. nasal cavity
9.3. larynx
9.4. oral cavity
9.5. parotid gland
9.6. thyroid
10. Work-up:
10.1. FNA
10.2. open biopsy if FNA tissue is insufficinet
11. Staging Work-up:
11.1. Labs
11.2. CXR to r/o mediastinal involvement
11.3. CT head/neck w/&w/o contrast
11.4. MRI chest/abd/pelvis
11.5. Bone marrow biopsy
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