MTHFR Related Health Problems
Stephen Smith MD NWHealthcare.net Agapenutrition.com
Definition
Methyl TetraHydro Folate Reductase Deficiency
Results in slower than nomal methylation processes
wiki
Heterozygous
Only one gene, Function 50 to 70%, 40% of population
Homozygous
Both genes affected, 7 to 10% of normal function, 30% of population
Types
50 variations
Most Common
677, Untitled
1298
677 +1298
Attributes
677
Elevated Homocysteine
Cardio Vascular Disease
Stroke
DVT (deep venous thrombosus)
Peripheral Neuropathy
Still Births
Pre-Eclampsia, Neural tube, cleft lip
1298
Depression, anxiety, IBS
Fibromyalgia
Chronic Fatigue
Dementia
Schizophrenia
Parkinson's
TetraHydroBiopterin Problems (BH4)
Migraines
677 + 1298
Symptoms of both defects
More Severe
Blood clots
All have problems
Clearing heavy metals, Lead, Mercury, Aluminum
Symptoms progress with time
Cancer risk increased
Renal failure
Addiction Potential, Drugs, Video Games, Pornography
Aggravating Factors
Heavy metal exposure, amalgams, vaccines, fish, aluminum cookware, occupational
Poor Diet, processed foods, hydrogenated fats
Anesthesia
Other Enzyme Defects
Comorbid Disease, Diabetes, Lymphoma, Leiden Factor V
Helpful Measures
Dietary, vegetables, berries, fruits
Exercise
Music
Treatment
Supplements
MB12, Not absorbed orally, Compounded, Inj. every 3 days
Methyl donors, DMG, TMG (Betaine)
Fatty Acids, Fish Oils, Flax Seed
Minerals, Zinc, 20 -40mg/day, Selenium, Magnesium
Vitamins, Vit E, Vit C, Amino Acids, B Complex
Herbs, Silymarin, Liver detoxifier
Medications
Active Forms of Folate, MetaNx, Neevo, Deplin, Cerefolin, L methyl folate, Hard to find
Diet
Avoid
Hydrogenated fats
Processed Foods
Increase
Vegetables
Fruits
Toxin Control
Avoid
Household chemicals, Art Scents, cleansers, Pesticides
Chronic Chemical Exposures
Detoxification
Nutritional Plan
Body Cleansers
InfraRed Sauna
Clay Baths
Rules
Fix bowel 1st
Do Slowly
Lab Testing
Blood
Common Labs, Liver enzymes, Ferritin, Homocysteine, HS Crp
Genetic, MTHFR Profile
Nitro Tyrosine, Measures oxidative stress, Special Lab only
Glutathione
B12, May be high, body unable to use
Urine
Heavy Metal Challenge
Urine Organic Acids
Toxin Screen
Misc
GI Health, If GI symptoms present
Food Allergy
