CHOLINERGIC : ANTAGONIST

1. MUSCARINIC ANTAGONIST

1.1. -An agent that have high binding affinity for the muscarinic receptor but have no intrinsic activity - Competitive (reversible) Antagonists of Acetylcholine (muscarinic agonist) COMMON NAMES: - Anticholinergic, Antimuscarinic, Cholinergic Blockers, Antipasmodics, Parasympatholytic

1.2. EXAMPLES OF DRUG

1.2.1. Tertiary Amines

1.2.1.1. Atropine

1.2.1.2. Scopolamine

1.2.1.3. Homatropin

1.2.1.4. Benztropin

1.2.1.5. Pirenzipine

1.2.1.6. Dicyclomide

1.2.1.7. Tropicamide

1.2.2. Quartenary Amines

1.2.2.1. Propantheline

1.2.2.2. Glycopyrrolate

1.2.2.3. Ipratropium

1.2.2.4. Tiotropium bromide

2. NICOTINIC ANTAGONIST

2.1. Compounds that bind to cholinergic nicotinic receptors with no intrinsic efficacy (competitive antagonists with Ach) *DO NOT CONFUSE WITH SKELETAL MUSCLE RELAXANT THAT PRODUCE THEIR EFFECT THROUGH CNS*

2.1.1. SKELETAL NEUROMUSCULAR AGENTS

2.1.1.1. ANTAGONIST : Pancuronium (non-depolarising)

2.1.1.1.1. CLINICAL INDICATIONS:

2.1.1.2. DEPOLARISING (AGONIST): Succinylcholine

2.1.1.2.1. CLINICAL INDICATIONS:

2.1.2. GANGLIONIC BLOCKING AGENTS

2.1.2.1. ANTAGONISTS

2.1.2.1.1. Mecamylamine

2.1.2.1.2. Trimetaphan