Parkinson's Disease

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Parkinson's Disease by Mind Map: Parkinson's Disease

1. constipations

2. pharmacological

2.1. Placebo effect ?

2.2. Side Effects

2.2.1. sleep disorders

2.2.2. drug interactions

2.2.3. L-Dopa

2.2.3.1. dyskinesia

2.2.3.2. on/off effects

2.2.3.3. nausea

2.2.4. psychosis

2.2.5. Abnormal sex behaviour

2.3. Oral treatment

2.3.1. Drugs

2.3.1.1. L-Dopa

2.3.1.1.1. loss of efficiacy after some years

2.3.1.2. Carboxylase Inhibitors

2.3.1.2.1. Benserazide

2.3.1.2.2. Carbidopa

2.3.1.3. MAO-B Inhibitors

2.3.1.4. Anticholinergic

2.3.1.5. Amantadine

2.3.1.6. Dopamine Agonists

2.3.1.7. Combination of several drugs

2.3.1.8. COMT Inhibitors

2.4. Advanced (pump) treatment

2.4.1. Duodopa pump

2.4.2. Apomorphine pen/pump

3. Treatment of PD (incurable so far)

3.1. experimental

3.1.1. Stem Cell Therapy

3.1.2. TMS

3.1.3. gene therapy

3.2. social

3.2.1. Cyper-Support (Internet support)

3.2.2. Social care and Support

3.2.3. Doctor Patient Relationship

3.2.4. Family Support

3.3. Community

3.3.1. Awareness

3.3.2. Health Care Providers

3.3.2.1. specialist PD Nurses

3.3.3. Charity

3.3.4. Parkinsons' Patient Organisation

3.3.5. Home Care

3.4. other

3.4.1. Psychiatric/psychological therapy

3.4.2. physiotherapy

3.4.3. speech/language therapy

3.4.4. sport/physical exercise

3.4.5. diat

3.4.5.1. Role of natural fruits/ black berries

3.4.6. Faith/Religiousity

3.5. education

4. Babiński's sign absent

5. How to speed up transition from dishes and animal models to promising Phase I?

6. Funding

6.1. Non profits

6.1.1. Michael J Fox Foundation

6.1.2. Parkinson UK

6.2. Public

6.2.1. UK NHS

6.2.2. EU (Framework Programmes)

6.2.3. US NIH

6.3. Big Pharmas

6.4. Patients

6.4.1. Crowdfunding

6.5. National/International funding?

7. non-motor symptoms

7.1. sexual disfunctions

7.2. decreased libido

7.3. sleeping disorders

7.4. unmodulated voice

7.5. difficulty swallowing

8. motor symptoms

8.1. akinesy

8.2. rigidity

8.3. hipertony

8.4. loss of balance

8.5. choreic movements

8.6. diskinesia

8.7. movement disorders

8.7.1. fine movement disorders

8.7.2. small steps

9. tremor

10. surgical

10.1. Deep Brain Stimulation

10.2. Surgical Ablation

11. Epidemiology

11.1. 2:3 M:F

11.2. 55-75 years

11.2.1. New node

11.3. #2nd neurodegenerative disorder

11.4. early onset 21-30(genetic, toxins)

11.5. indications that 20% debut before age 40

12. Etiology

12.1. Genetics

12.1.1. Dominant Gene

12.1.2. Recessive Gene

12.1.3. Genetic mutations

12.1.3.1. SNCA

12.1.3.2. PARKIN

12.1.3.3. PINK

12.1.3.4. DY-1

12.1.3.5. LRRK2

12.2. Infectious

12.3. Toxic

12.3.1. Alcholic

12.3.2. Pesticides

12.3.3. MPTP

12.3.4. Copper

12.4. Unknown

12.5. Mitochondrial Dysfunction

12.6. Protein Agreggation

12.6.1. Amyloid

12.6.2. Lewy-Bodies

12.7. Drug Induced

12.7.1. Metoclopramide

12.7.2. Rotenone

12.8. Imunological

13. Symptoms

13.1. psychology

13.1.1. anxiety

13.1.2. depression

13.1.3. dementia

13.1.4. psychosis

13.1.5. hallucinations

13.1.6. apathy

13.1.7. changes in behaviour

13.1.7.1. gambling

13.1.7.2. isolation

13.2. disease-related?

13.3. drug-induced?

14. Physiopathology

14.1. DOPAMINE DOWN

14.1.1. New node

14.2. ACETYLCHOLINE UP

14.3. BASAL GANGLIA

14.4. SUBSTANTIA NIGRA

14.5. Dopamine Pathways

14.6. Links with other diseases

14.6.1. Neurodegenerative disease

14.6.2. Parkinson-Altzheimers connections

14.6.3. Parkinson plus diseases

14.6.3.1. Lewy-Body Dementia

14.6.3.2. Supranuclear Palsy

14.6.3.3. Multiple System Atrophy

14.6.4. Secondary Parkinsonism

14.6.4.1. Wilson's disease

14.6.4.2. Traumatic

14.6.4.3. Vascular

14.6.4.4. Medical induced

14.6.4.4.1. anti-psychotics

15. Social Aspects

15.1. Social Isolation

15.2. Public perception of disease

15.3. Social Burden

15.4. Patient Organisation

15.4.1. Parkinson UK

15.5. Economic Burden

15.6. Stigma

15.7. Effect of family

15.8. Famous Parkinson patients

15.8.1. Mohamed Ali

15.8.2. Pope Jean Paul II

15.8.3. Michael J.Fox

15.8.4. Hitler

15.8.5. Andy Grove

16. diagnosis

16.1. clinical examination

16.1.1. tendon reflexes

16.2. paraclinical examination

16.2.1. EEG

16.2.2. dopamine level measuring

16.2.3. ERPs

16.2.4. genetical testsn

16.2.5. DAT Scans

16.2.6. PET/SPECT scan

17. Psychology Aspects

17.1. Suicide

17.2. Deep damage

17.3. Fear of the unknown

17.4. Isolation

18. Research

19. Treatment

20. New node

21. New node