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Parkinson's Disease by Mind Map: Parkinson's Disease
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Parkinson's Disease

Parkinson's disease (also known as Parkinson disease, Parkinson's, idiopathic parkinsonism, primary parkinsonism, PD, or paralysis agitans) is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later, cognitive and behavioural problems may arise, with dementia commonly occurring in the advanced stages of the disease. Other symptoms include sensory, sleep and emotional problems. PD is more common in the elderly, with most cases occurring after the age of 50. The main motor symptoms are collectively called parkinsonism, or a "parkinsonian syndrome". Parkinson's disease is often defined as a parkinsonian syndrome that is...

constipations

pharmacological

Placebo effect ?

Side Effects

Oral treatment

Advanced (pump) treatment

Treatment of PD (incurable so far)

This is just a demo map that you can delete right away, if you feel like it...

experimental

social

Community

other

education

Babiński's sign absent

How to speed up transition from dishes and animal models to promising Phase I?

Funding

Non profits

Public

Big Pharmas

Patients

National/International funding?

non-motor symptoms

sexual disfunctions

decreased libido

sleeping disorders

unmodulated voice

difficulty swallowing

motor symptoms

akinesy

rigidity

hipertony

loss of balance

choreic movements

diskinesia

movement disorders

tremor

surgical

Deep Brain Stimulation

Surgical Ablation

Epidemiology

2:3 M:F

55-75 years

#2nd neurodegenerative disorder

early onset 21-30(genetic, toxins)

indications that 20% debut before age 40

Etiology

Genetics

Infectious

Toxic

Unknown

Mitochondrial Dysfunction

Protein Agreggation

Drug Induced

Imunological

Symptoms

psychology

disease-related?

drug-induced?

Physiopathology

DOPAMINE DOWN

ACETYLCHOLINE UP

BASAL GANGLIA

SUBSTANTIA NIGRA

Dopamine Pathways

Links with other diseases

Social Aspects

Social Isolation

Public perception of disease

Social Burden

Patient Organisation

Economic Burden

Stigma

Effect of family

Famous Parkinson patients

diagnosis

clinical examination

paraclinical examination

Psychology Aspects

Suicide

Deep damage

Fear of the unknown

Isolation

Research

Treatment

New node

New node