Biologics

1. mAb

1.1. Biosimilar

1.2. Chimeric

1.2.1. "-xi" = rituximab (Remicade) Human (C) & Murine (V) region -Autoimmunity

1.3. Murine

1.3.1. "-o" = muromonab-CD3 (OKT-3) Entirely murine -Transplantion

1.4. Humanized

1.4.1. "-zu" = bevacizumab (Avastin) Human scaffold with murine CDRs -Treats cancer

1.5. Human

1.5.1. "-u" = adalimumab (Humira) Entirely human -Autoimmunity

2. Treatment

2.1. Small Molecule Therapeutics

2.2. HAMA

2.3. Protein therapeutics

2.3.1. Soluble receptors

2.3.2. Avastin

3. Responses

3.1. Immunogenicity

3.1.1. Anaphylaxis

3.1.2. Serum Sickness

3.2. Infections

3.2.1. TB

3.3. HAMA

4. Research

4.1. ELISA

4.2. FACS

4.3. Immunoelectron Microscopy

4.4. Western Blots

4.5. Affinity Purification

5. mAb Mechanism of Action:

5.1. ~Blocks action of antagonist ~Functions as agonist ~Cell targeting -CDC -ADCC