1. Precautions and Contraindications: -Avoid pts with hypeprsensitivity to rifamycin and rifabutin -Parenteral rifampin should not be administered to pts with sulfite hypersensitivity -Pts with hepatic dysfunction
2. -Associations with serious or potentially fatal anaphylactic reactions -Pts with known alcoholism
3. Adverse Effects: -Hepatic injury -discoloration of body fluids- urine, saliva, tears, and speutum -GI disturbances -High dose=flu-like syndrome
3.1. -Monitor CBC -Monitor PFTs -Monitor LFTs
4. Drug Interactions: -Potent P450 inducer -May result reduced concentration of other drugs -When drugs are given concurrently, dosage may need to be increased
5. Maximizing Therapeutic Efffects: -Do not use alone because resistance develops rapidly. -Direct Observational Therapy
6. Pathophys: -TB is a mycobaterial bacterial infection usually found in the lungs -TB is spead via airborne particles called droplet nuclei
7. Pharmacokinetics: -Administered PO or parenterally. -Well absorbed by GI, unless with food -Widely distributed throughout the body -Enters CSF at 10 to 20% of plasma concentration -Metabolized by liver as active metabolite -Excreted through biliary elimination in feces
8. Pharamacotherapeutics: -Used for treating leprosy, meningococcal infectious disease, MAC infection, and first line in treating TB
