COPDS

1. Indacaterol

1.1. brand name: Arcapta Neohale

1.2. Mechanisim of Action : Indacaterol maleate is a long-acting beta-2-adrenergic agonist and when inhaled, acts locally as a bronchodilator in the lungs. This is accomplished via stimulation of intracellular adenyl cyclase which is responsible for catalyzing the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (AMP). Increased AMP levels causes relaxation of the bronchial smooth muscle

1.3. FDA approved: 7/01/2011

1.4. Drug Class: anticholinergics

2. Glycopyrrolate

2.1. Brand Names: Lonhala Magnar, Sebri, Bvespi

2.2. Drug Class: anticholinergics

2.3. FDA approved: 10/29/2015

2.4. Mechanism of Action:

3. Umeclidinium

3.1. Brand name: Incruse Ellipta

3.2. Drug class: anticholinergics

3.3. Mechanism for action: Umeclidinium is an anticholinergic that causes bronchodilation by inhibiting the M3 receptors on the smooth muscle of the airways

3.4. FDA approved: May 2014

4. Aclidinium bromide

4.1. Brand name: Tudorza

4.2. Drug Class: anticholinergics

4.3. Mechanisum for Action: Aclidinium bromide is a long-acting antimuscarinic agent that inhibits the M(1) through M(5) receptors. Inhaled aclidinium bromide inhibits the M(3) receptor at the smooth muscle in the airways, leading to bronchodilation