1. Type I
1.1. Characteristics
1.1.1. Allergy (immediate)
1.1.2. IgE mediated response
1.1.3. Developed < 1 hr after exposure to allergen
1.2. Release of mediators result in
1.2.1. Vasodilation
1.2.2. Increased capillary permeability
1.2.3. Mucus hypersecretion
1.2.4. Smooth muscle spasm
1.3. Examples
1.3.1. Atopic disorders
1.3.1.1. Allergic asthma
1.3.1.2. Allergic rhinitis
1.3.1.3. Eczema
1.3.2. Anaphylactic shock
2. Type III
2.1. Characteristics
2.1.1. Immune complex disease
2.1.2. Antigen-antibody reaction
2.1.3. Cause systemic immune response
2.1.4. Develops 4-10 days after exposure to antigen. Chronic if exposure continues.
2.2. Examples
2.2.1. Serum sickness
2.2.2. Systemic Lupus Erythematosus (SLE)
2.2.3. Rheumatoid arthritis
2.2.4. Leukocytoclastic vasculitis
2.2.5. Hypersensitivity pneuomonitis
3. Type II
3.1. Characteristics
3.1.1. Cytotoxic, antibody-dependent
3.1.2. IgG or IgM, complement or MAC mediated
3.2. Examples
3.2.1. Hyperacute graft rejection of an organ or graft transplant
3.2.2. Autoimmune hemolytic anemia
3.2.3. Hashimoto thyroiditis
3.2.4. Anti-glomerular basement membrane disease
4. Type IV
4.1. Characteristics
4.1.1. Delayed hypersensitivity
4.1.2. T-cell mediated
4.1.3. T-cells are activated by re-exposure to antigen
4.1.4. Tissue damage through direct toxic effect or the release of cytokines
4.2. Examples
4.2.1. Contact dermatitis
4.2.2. Hypersensitivity pneumonitis
4.2.3. Immune response to TB
4.2.4. Some forms of drug hypersensitivity
4.2.5. Coeliac disease