1. Acute Lymphocytic Leukemia
1.1. Acute-Fast Growing
1.2. 75% of Childhood Cancer
1.3. Lymphocytic
1.3.1. B cells
1.4. symptoms
1.4.1. splenomegaly, hepatomegaly, lymphadenopathy
1.4.2. anemia
1.4.3. thrombocytopenia
1.4.4. leukopenia
1.4.5. multiple unresponsive infections
2. Acute Myelogenous Leukemia
2.1. Acute-Fast Growing
2.1.1. leading to hypermetabolism causing anorexia, fever, bone pain
2.2. Non functional granulocytic stem cells
2.2.1. myeloid stem cell becomes RBCs, platelets and granulocytic WBC
2.3. Adults
2.4. Symptoms
2.4.1. anemia
2.4.1.1. RBC depression because stem cell is not functional
2.4.2. thrombocytopenia
2.4.2.1. decrease in platelets
2.4.2.2. bleeding and bruising
2.4.3. leukopenia
2.4.3.1. low WBC
2.4.4. multiple unresponsive infections
3. Chronic Lymphocytic Leukemia
3.1. 1/3 of leukemia
3.2. adults rarely seen under 40
3.2.1. leukocytosis, weakness and fatigue, anemia and thrombocytopenia
3.2.1.1. 4-5 years with effective treatment prognosis
3.3. B cells
3.4. Characterized by aggression
3.4.1. indolent
3.4.1.1. largely asymtomatic
3.4.1.2. found during blood work
3.4.1.3. leukocytosis is only common symptom
3.4.2. aggressive
3.4.2.1. lymphadenopathy
3.4.2.2. hepatosplenomegaly
3.4.2.2.1. gross enlargement
3.4.2.3. abdominal pain
3.4.2.4. thrombocytopenia
3.5. diagnostic WBC more than 20,000 and up to several hundred thousand
3.5.1. 78-95% of lymphocytes compared to normal 25% of WBC
4. Chronic Myelogenous Leukemia
4.1. 10-15% of leukemias
4.2. older adults, average age is 67
4.3. Granulocytic Stem Cells
4.3.1. hematopoetic stem cell has Philadelphia chromosome abnormality
4.4. Phases
4.4.1. Chronic
4.4.2. Acclerated
4.4.2.1. enlargement of spleen and progressive symptoms
4.4.2.1.1. 6-12 months prognosis
4.4.3. Terminal/Blast Crisis
4.4.3.1. evolution to acute leukemia, blast cells more than 100k cells
4.4.3.1.1. 3 months prognosis