Year One
by Nicola Hodgson
1. Pharmaceutics
1.1. Basic concepts (British Pharmacopoeia)
1.2. Solubility definitions & units
1.3. Factors influencing solubility
1.4. Solvents, cosolvents & dissolution
1.5. Solubility problems (and solutions) in formulation
1.6. The nasal route
1.7. Structure and solution properties of peptides and proteins
1.8. Activity and chemical potential
1.9. Biopharmaceutical importance of particle size
1.10. Amphipathic compounds / surfactants
1.11. Surface and interfacial properties of surfactants
1.12. Emulsion dosage forms
1.13. Micellisation, solubilisation & other vesicles
1.14. Pharmaceutical polymers
1.15. Water-soluble polymers
1.16. Suspension dosage forms
1.17. Thermodynamics: a brief introduction
1.18. The chemical decomposition of drugs
1.19. Kinetics of chemical decomposition in solution
1.20. Stability testing and prediction of shelf-life
1.21. The oral route and oral absorption
1.22. Oral dosage forms
1.23. Biological membranes and drug transport
1.24. Partitioning
2. Pharmacology
2.1. What is pharmacology
2.2. How drugs act: general principles (drug receptors and drug-receptor interactions)
2.3. How drugs act: molecular aspects
2.4. How drugs act: cellular aspects — excitation, contraction and secretion
2.5. Cell proliferation, apoptosis, repair and regeneration
2.6. Cellular mechanisms: host defence
2.7. Method and measurement in pharmacology (e.g. bioassays, animal models, clinical trials)
2.8. Absorption and distribution of drugs
2.9. Drug metabolism and elimination
2.10. Pharmacokinetics
3. Cell biology and biochemistry
3.1. Basic concepts of life: The basic molecular themes of life
3.2. Cells and viruses
3.3. Energy consideration in biochemistry
3.4. Structure and function of proteins and membranes: The structure of proteins
3.5. Methods in protein investigation
3.6. Enzymes
3.7. The cell membrane and membrane proteins
3.8. Muscle contraction, the cytoskeleton and molecular motors
3.9. Metabolism and nutrition: General principles of nutrition
3.10. Food digestion, absorption and distribution to the tissues
3.11. The storage fuels: mechanisms of transport, storage, and mobilisation of carbohydrate and fat
3.12. Principles of energy release from food
3.13. Glycolysis, the TCA cycle and the electron transport system
3.14. Energy release from fat
3.15. An alternative pathway of glucose oxidation: the pentose phosphate pathway
3.16. The synthesis of glucose (gluneogenesis)
3.17. Synthesis of fat and related compounds
3.18. Nitrogen metabolism: amino acid metabolism
3.19. Nitrogen metabolism: nucleotide metabolism
3.20. Mechanisms of metabolic control and their applications to metabolic integration
3.21. Raising electrons of water back up the energy scale: photosynthesis
3.22. Information storage and utilisation: the genome
3.23. DNA synthesis, repair and recombination
3.24. Gene transcription
3.25. Protein synthesis and controlled protein breakdown
3.26. Control of gene expression
3.27. Protein sorting and delivery
3.28. Manipulating DNA and genes
3.29. Cells and tissues
3.30. Cell signalling
3.31. The cell cycle, cell division, cell death and cancer
3.32. Manipulating DNA and genes
3.33. Molecular biology and health disease: Special topics: blood clotting, xenobiotics metabolism and reactive oxygen species
3.34. The immune system (innate)
3.35. The cell cycle and its control
3.36. Apoptosis
3.37. Cancer
4. Pharmacy Practice
4.1. The Pharmacy Contract
4.2. Sale and supply of medicines (FMD/Robotics)
4.3. Political and legal framework (Data protection/GDPR/Digital Threats)
4.4. Social and behavioural science
4.5. Health promotion
4.6. Disease prevention
4.7. Workplace regulation
4.8. Ethical Considerations
4.9. Product specific counselling
4.10. Pharmaceutical Calculations
4.11. Communication Skills (including Skype)
4.12. Fitness to practise
4.13. Pre-Placement sessions
4.14. Placements (1 x community)
4.15. What is pharmacy? Who is the pharmacist?
4.16. Induction
4.17. Academic Skills
4.18. First Aid
5. Pharmaceutical Chemistry
5.1. Basic concepts (SI units, IUPAC, states of matter, concentrations, etc.)
5.2. Thermochemistry
5.3. Atoms and atomic structure
5.4. Homonuclear covalent bonds
5.5. Heteronuclear diatomic molecules
5.6. Polyatomic molecules: shapes
5.7. Polyatomic molecules: bonding
5.8. Ions
5.9. Elements
5.10. Mass spectrometry
5.11. Introduction to spectroscopy (Vibrational and rotational spectroscopies)
5.12. Electronic spectroscopy
5.13. NMR spectroscopy
5.14. Reaction kinetics
5.15. Equilibria
5.16. Thermodynamics
5.17. Electrochemistry
5.18. The conductivity of ions in solution
5.19. Periodicity
5.20. Hydrogen and the s-block elements
5.21. p-Block and high oxidation state d-block elements
5.22. Coordination complexes of the d-block metals
5.23. Carbon compounds: an introduction
5.24. Acyclic and cyclic alkanes
5.25. Alkenes and alkynes
5.26. Polar organic molecules: an introduction
5.27. Halogenoalkanes
5.28. Ethers
5.29. Alcohols
5.30. Amines
5.31. Aromatic compounds
5.32. Carbonyl compounds
5.33. Aromatic heterocyclic compounds
5.34. Molecules in nature
5.35. Drugs and drug targets:
5.36. Protein structure and function
5.37. Enzymes: structure and function
6. Anatomy and physiology
6.1. Organisation and general plan of the body
6.2. Some basic chemistry
6.3. Cells
6.4. Tissues and membranes
6.5. The integumentary system
6.6. The skeletal system
6.7. The muscular system
6.8. The nervous system
6.9. The senses
6.10. The endocrine system
6.11. Blood
6.12. The heart
6.13. The vascular system
6.14. The lymphatic system and immunity
6.15. The respiratory system
6.16. The digestive system
6.17. Body temperature and metabolism
6.18. The urinary system
6.19. Fluid-electrolyte and acid-base balance
6.20. The reproductive systems
6.21. Human development and genetics
6.22. An introduction to microbiology and human disease
7. Clinical Pharmacy
7.1. Routes of administration
7.2. Evidence Based Medicine
7.3. Symptoms in the pharmacy
7.4. Differential diagnosis
7.5. Diagnostic tests
7.6. Health information systems/resources
7.7. Health-related quality of life
7.8. Pharmacovigilance
