Drug discovery and development of natural products (flavonoids), angiotensin peptides, antioxidants in cardiovascular and metabolic disorders.
Professor of Pharmacology
Dean, Health and Translational Medicine Cluster, University of Malaya
PROFESSOR & DEPUTY DEAN (RESEARCH) Faculty of Medicine. Sept 2009 - June 2011
HEAD, Department of Pharmacology, Faculty of Medicine, Sept 2007 - Aug 2009
HEAD, Sponsored Research Unit, IPPP, UM, June 2005 - Aug 2007
2012, Erectogenic effects of Clerodendron capitatum: involvement of phosphodiesterase type-5 inhibition. Evidence-Based Complementary and Alternative Medicine., Abdelwahab SI, Koko WS, Taha MME, Mohan S, Achoui M, Abdulla MA, et al. In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-ÎºB translocation. European journal of pharmacology. 2012;678(2012):61-70., Zandi K, Lani R, Wong P-F, Teoh B-T, Sam S-S, Johari J, et al. Flavone Enhances Dengue Virus Type-2 (NGC Strain) Infectivity and Replication in Vero Cells. Molecules. 2012;17(3):2437-45, Yeh-Siang L, Ajay M, Achike FI, Murugan D, Mustafa MR. The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats. Experimental Biology and Medicine. 2012;237(1):93-8., Tan PJ, Appleton DR, Mustafa MR, Lee HB. Rapid Identification of Cyclic Tetrapyrrolic Photosensitisers for Photodynamic Therapy Using On-line Hyphenated LC-PDA-MS Coupled with Photo-cytotoxicity Assay. Phytochemical Analysis. 2012;23(1):52-9., Tan KW, Seng HL, Lim FS, Cheah SC, Ng CH, Koo KS, et al. Towards a selective cytotoxic agent for prostate cancer: Interaction of zinc complexes of polyhydroxybenzaldehyde thiosemicarbazones with topoisomerase I. Polyhedron. 2012;38 (2012):275-84., Liew SY, Mukhtar MR, Hadi AHA, Awang K, Mustafa MR, Zaima K, et al. Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis. Molecules. 2012;17(4):4028-36., Lai SL, Cheah SC, Wong PF, Noor SM, Mustafa MR. In Vitro and In Vivo Anti-Angiogenic Activities of Panduratin A. PLoS One. 2012;7(5):e38103., Khan A, Ullah R, Mustafa MR, Hussain J, Murugan DD, Hadi AHBA. Vasodilator Effect of Phlomis bracteosa Constituents Is Mediated through Dual Endothelium-Dependent and Endothelium-Independent Pathways. Clinical and experimental hypertension. 2012;34(2):132-9., Isa NM, Abdelwahab SI, Mohan S, Abdul AB, Sukari MA, Taha MME, et al. In vitro anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A, a chalcone isolated from Boesenbergia rotunda (L.)(fingerroot). Brazilian Journal of Medical and Biological Research. 2012(REVIEW):0-., Arya A, Achoui M, Cheah SC, Abdelwahab SI, Narrima P, Mohan S, et al. Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. Evidence-Based Complementary and Alternative Medicine. 2012;2012.
2011, Zandi K, Teoh BT, Sam SS, Wong PF, Mustafa MR, AbuBakar S. In vitro antiviral activity of Fisetin, Rutin and Naringenin against Dengue virus type-2. Journal of Medicinal Plants Research. 2011;5(23):5534–9., Yeh-Siang L, Subramaniam G, Hadi AHA, Murugan D, Mustafa MR. Reactive Oxygen Species-Induced Impairment of Endothelium-Dependent Relaxations in Rat Aortic Rings: Protection by Methanolic Extracts of Phoebe grandis. Molecules. 2011;16(4):2990-3000., Liew SY, Mukhtar MR, Awang K, Mustafa MR, Ng SW. 1-(1-Hydroxyethyl)-7, 8-dihydroindolo [2, 3-a] pyridine [3, 4-g] quinolizin-5 (13H)-one (angustoline) monohydrate from Nauclea subdita (Rubiaceae). Acta Crystallographica Section E: Structure Reports Online. 2011;67(7):o1727-o8., Leong XF, Salimon J, Mustafa MR, Jaarin K. Effect of Repeatedly Heated Palm Olein on Blood Pressure Regulating Enzymes Activity and Lipid Peroxidation in Rats. The Malaysian Journal of Medical Sciences. 2011;19(1):20-9., Lee ST, Wong PF, Cheah SC, Mustafa MR. Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells. PLoS One. 2011;6(4):e18915., Jaarin K, Mustafa MR, Leong XF. The effects of heated vegetable oils on blood pressure in rats. Clinics. 2011;66(12):2125-32, Chong YM, Yin WF, Ho CY, Mustafa MR, Hadi AHA, Awang K, et al. Malabaricone C from Myristica Cinnamomea Exhibits Anti-Quorum Sensing Activity. Journal of Natural Products. 2011;74(10):2261-4., Cheah SC, Appleton DR, Lee ST, Lam ML, Hadi AHA, Mustafa MR. Panduratin A Inhibits the Growth of A549 Cells through Induction of Apoptosis and Inhibition of NF-KappaB Translocation. Molecules. 2011;16(3):2583-98., Aloysuis UI, Achike FI, Mustafa MR. Mechanisms underlining gender differences in Phenylephrine contraction of normoglycaemic and short-term Streptozotocin-induced diabetic WKY rat aorta. Vascular pharmacology. 2011.
2010, Muharis SP, Top AGM, Murugan D, Mustafa MR. Palm oil tocotrienol fractions restore endothelium dependent relaxation in aortic rings of streptozotocin-induced diabetic and spontaneously hypertensive rats. Nutrition Research. 2010;30(3):209-16., Leong XF, Mustafa MR, Das S, Jaarin K. Association of elevated blood pressure and impaired vasorelaxation in experimental Sprague-Dawley rats fed with heated vegetable oil. Lipids Health Dis. 2010;9:66., Khan H, Ali I, Khan AU, Ahmed M, Shah Z, Saeed A, et al. Purification and Biochemical Characterization of Alkaline Serine Protease from Caesalpinia Bonducella. Natural Product Communication. 2010;5(6):931-4., Kassim M, Achoui M, Mustafa MR, Mohd MA, Yusoff KM. Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity. Nutrition Research. 2010;30(9):650-9., Achoui M, Appleton D, Abdulla MA, Awang K, Mohd MA, Mustafa MR. In Vitro and In Vivo Anti-Inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF-ÎºB Translocation and IKKÎ² Activity. PLoS One. 2010;5(12):e15105.
2009, Subramaniam G, Achike FI, Mustafa MR. Characterizing the Mechanisms of Insulin Vasodilatation of Normal and Streptozotocin-induced Diabetic Rat Aorta. Journal of cardiovascular pharmacology. 2009;53(4):333., Subramaniam G, Achike FI, Mustafa MR. Effect of acidosis on the mechanism (s) of insulin-induced vasorelaxation in normal Wistar-Kyoto (WKY) rat aorta. Regulatory peptides. 2009;155(1-3):70-5., Leong XF, Najib MNM, Das S, Mustafa MR, Jaarin K. Intake of repeatedly heated palm oil causes elevation in blood pressure with impaired vasorelaxation in rats. The Tohoku journal of experimental medicine. 2009;219(1):71-8., Chung LY, Soo WK, Mustafa MR, Goh SH, Imiyabir Z. 5-Hydroxytryptamine (2A) Receptor Binding Activity of Compounds from Litsea Sessilis. Phytotherapy Research. 2009;23(2):330-4., Chung LY, Soo WK, Mustafa MR, Goh SH, Imiyabir Z. 5-Hydroxytryptamine1A receptor binding activity of bisbenzyltetrahydroisoquinoline alkaloids from Popowia odoardi. Pharmaceutical Biology. 2009;47(12):1130-6., Chung LY, Soo WK, Chan KY, Mustafa MR, Goh SH, Imiyabir Z. Lipoxygenase inhibiting activity of some Malaysian plants. Pharmaceutical Biology. 2009;47(12):1142-8.
2008, Mukhtar MR, Hadi AHA, Rondeau D, Richomme P, Litaudon M, Mustafa MR, et al. New proaporphines from the bark of Phoebe scortechinii. Natural Product Research. 2008;22(11):921-6., Einstein JW, Mustafa MR, Nishigaki I, Rajakapor B, Mustafa AM. Protective Effect of Different Parts of Cassia Fistulla on Human Umbilical Vein Endothelial Cells Against Glycated Protein-Induced Toxicity in-vitro. Methods and Fillings in Experimental and Clinical Pharmacology. 2008;30(8):599-605., Dharmani M, Mustafa MR, Achike FI, Sim MK. Involvement of AT1 angiotensin receptors in the vasomodulatory effect of des-aspartate-angiotensin I in the rat renal vasculature. Peptides. 2008;29(10):1773-80., Chung LY, Yap KF, Goh SH, Mustafa MR, Imiyabir Z. Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata. Phytochemistry. 2008;69(7):1548-54., Amudha K, Choy AM, Mustafa MR, Lang CC. Short-term Effect of Atorvastatin on Endothelial Function in Healthy Offspring of Parents with Type 2 Diabetes Mellitus. Cardiovascular Theraputics. 2008;26(4):253-61.
2007, Machha A, Achike FI, Mustafa AM, Mustafa MR. Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas. Nitric Oxide. 2007;16(4):442-7., Machha A, Achike FI, Mohd MA, Mustafa MR. Baicalein impairs vascular tone in normal rat aortas: Role of superoxide anions. European journal of pharmacology. 2007;565(1-3):144-50., Dharmani M, Mustafa MR, Achike FI, Sim MK. Effects of angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and streptozotocin-induced diabetic rats. European journal of pharmacology. 2007;561(1-3):144-50., Chin LC, Achike FI, Mustafa MR. Hydrogen peroxide modulates angiotensin II-induced contraction of mesenteric arteries from streptozotocin-induced diabetic rats. Vascular pharmacology. 2007;46(3):223-8., Awang K, Mukhtar MR, Mustafa MR, Marc l, Khozirah s, Mohamad K, et al. New alkaloids from Phoebe scortechinii. Natural Product Research. 2007;21(8):704-9., Ajay M, Chai HJ, Mustafa AM, Gilani AH, Mustafa MR. Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. Journal of ethnopharmacology. 2007;109(3):388-93., Ajay M, Achike FI, Mustafa MR. Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid. Pharmacological research. 2007;55(5):385-91.
2006, Othman R, Ibrahim H, Mohd MA, Mustafa MR, Awang K. Bioassay-guided isolation of a vasorelaxant active compound from Kaempferia galanga L. Phytomedicine. 2006;13(1-2):61-6., Ajay M, Mustafa MR. Effects of ascorbic acid on impaired vascular reactivity in aortas isolated from age-matched hypertensive and diabetic rats. Vascular pharmacology. 2006;45(2):127-33., Ajay M, Achike FI, Mustafa AM, Mustafa MR. Effect of quercetin on altered vascular reactivity in aortas isolated from streptozotocin-induced diabetic rats. Diabetes research and clinical practice. 2006;73(1):1-7., Ajay M, Achike FI, Mustafa AM, Mustafa MR. Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: comparative study with ascorbic acid. Clinical and experimental pharmacology and physiology. 2006;33(4):345-50.
2005, Mustafa MR, Mahmood AA, Sidik K, Noor SM. Evaluation of wound healing potential of Ageratum conyzoides leaf extract in combination with honey in rats as animal model. International Journal of Molecular Medicine and Advance Sciences. 2005;1(4):406-10., Machha A, Mustafa MR. Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. Journal of cardiovascular pharmacology. 2005;46(1):36-40., Dharmani M, Mustafa MR, Achike FI, Sim MK. Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ-induced diabetic rats. Regulatory peptides. 2005;129(1-3):213-9., Chung LY, Yap KF, Mustafa MR, Goh SH, Imiyabir Z. Muscarinic receptor activity of some Malaysian plant species. Pharmaceutical Biology. 2005;43(8):672-82.
2004, Mustafa MR, Dharmani M, Kunheen NK, Sim MK. Effects of des-aspartate-angiotensin I on the actions of angiotensin III in the renal and mesenteric vasculature of normo-and hypertensive rats. Regulatory peptides. 2004;120(1-3):15-22.
2003, Lang CC, Jamal SK, Mohamed Z, Mustafa MR, Mustafa AM, Lee TC. Evidence of an interaction between nifedipine and nafcillin in humans. British journal of clinical pharmacology. 2003;55(6):588-90., Ajay M, Gilani AH, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life sciences. 2003;74(5):603-12.
2002, Othman R, Ibrahim H, Mohd MA, Awang K, Gilani AH, Mustafa MR. Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta. Planta medica. 2002;68(7):655-7.
2001, Mustafa MR, Johns EJ. The role of haem oxygenase in renal vascular reactivity in normotensive and hypertensive rats. Journal of hypertension. 2001;19(6):1105-11.
2000, Mustafa MR, Gibbs PJ, Wise MH. Cadaveric renal transplantation with simultaneous iliac bypass. JRSM. 2000;93(1):26-7., Mustafa MR, Achike FI. Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation. Acta pharmacologica Sinica. 2000;21(12):1165-8.
1995, Orchard CH, Mustafa MR, White E. OSCILLATIONS AND WAVES OF INTRACELLULAR [CA2+] IN CARDIAC-MUSCLE-CELLS. Chaos Solitons & Fractals. 1995 Mar-Apr;5(3-4):447-58., Mustafa MR, White E, Hongo K, Othman I, Orchard CH. THE MECHANISM UNDERLYING THE CARDIOTOXIC EFFECT OF THE TOXIN FROM THE JELLYFISH CHIRONEX FLECKERI. Toxicology and Applied Pharmacology. 1995 Aug;133(2):196-206., Mustafa MR, Mohamad R, Din L, Wahid S. Smooth muscle relaxant activities of compounds isolated from malaysian medicinal plants on rat aorta and guinea pig ileum. Phytotherapy Research. 1995;9(8):555-8.
M. Ajay and M.R. Mustafa (2008). Vascular Protective Effects of Flavonoids in Animal Models of Hypertension and Diabetes. In Polyphenols and Health: New and Recent advances. Editor: Neville Vasallo. Nova Science Publishers, USA. (Non-ISI/Non-SCOPUS Cited Publication)