1. TSAb
1.1. Autoimmunity
1.1.1. Environmental factors
1.1.2. Genetic Factors
2. Hyperthyroidism
2.1. opthalmopathy
2.1.1. functional abnormalities
2.1.1.1. lag of globe on upward gaze
2.1.1.2. lag of upper lid on downward gaze
2.1.2. infiltrative changes
2.1.2.1. orbital fat accumulation
2.1.2.2. exophthalmos (eyeball protrusion)
2.1.2.2.1. can cause damage to optic nerve
2.1.2.3. periorbital edema
2.2. endocrine system (thyroid)
2.2.1. enlarged goiter
2.2.1.1. hyperactivity of thyroid gland
2.2.2. systolic bruit over thyroid
2.3. reproductive system
2.3.1. oligomenorrhea or amenorrhea
2.3.1.1. related to hypothalamic and pituitary changes
2.4. GI
2.4.1. weight loss
2.4.1.1. increased metabolism, glucose absorption
2.4.2. frequent stools
2.5. cardiovascular
2.5.1. tachycardia
2.5.1.1. increased metabolism
2.6. nervous system
2.6.1. restlessness
2.6.1.1. increased cerebral metabolism
2.6.2. short attention span
2.6.3. fatigue
2.6.4. tremor
2.6.5. insomnia
2.6.5.1. Increased circulation related to increased metabolism
2.7. respiratory
2.7.1. dyspnea
2.7.1.1. weakness of respiratory muscles
2.8. skin
2.8.1. sweating
2.8.2. warm skin
2.8.3. heat intolerance