MEASUREMENT OF DISSOLUTION RATES

1. ROTATING BASKET METHOD

1.1. stainless steel wire basket

1.2. speed: fixed

1.3. wide-mouthed cylindrical vessel

2. PADDLE METHOD

2.1. agitator: rotating paddle

2.2. wide-mouthed cylindrical vessel

2.3. spherical bottom

3. ROTATING AND STATIC DISC METHOD

3.1. compound is compressed into a non-disintegrating disc

3.2. one surface is exposed to medium

3.3. immersed at fixed position ( static disc method) or rotated at given speed (rotating disc method)

3.4. assumption: surface area remain constant

3.5. used to determine intrinsic dissolution rate

3.5.1. amount of substance dissolved per unit time and unit surface area

4. BEAKER METHOD

4.1. 400ml Beaker

4.2. 250 ml Dissolution Medium

4.3. Agitator: 3-bladed polyethylene stirrer (50mm diameter)

4.4. immersed at 27 mm depth

4.5. speed: 60 rpm

5. FLASK-STIRRED METHOD

5.1. same as beaker method except beaker

5.2. round bottom flask

5.3. prevent formation of mounds of particles