1. Non-Hodgkin’s Lymphoma (NHL)
1.1. Pathophysiology: Proliferation of abnormal B cells, T cells or NK cells
1.1.1. Signs and symptoms
1.1.1.1. Lymphatic blockage
1.1.1.1.1. Lymphendema or nerve impingment
1.1.1.1.2. Numbness & tingling
1.1.1.2. Fever
1.1.1.3. Chills
1.1.1.4. Night Sweats
1.1.1.5. Weight Loss
1.1.1.6. Fattigue
1.1.2. Physical Assessment Findings
1.1.2.1. Painless enlarged lymp node, splenomegaly, hepatomegaly
1.1.2.2. Lymphedema
1.1.2.3. Nerve impingement leading to weakness & sensory loss in an extremity
1.1.3. Diagnostic Testing
1.1.3.1. CBC with differential
1.1.3.2. HIV serology
1.1.3.3. Serum chemistry
1.1.3.4. Serum lactate dehydrogenase level
1.1.3.5. Chest X-ray
1.1.3.6. Lymph node biopsy
1.1.3.7. Bone marrow aspirate
1.1.3.8. Excessive WBC's in CBC & bone marrow
1.1.3.9. HIV-positive status often associated with NHL
1.1.4. Treatment
1.1.4.1. Chemotherapy
1.1.4.2. Bone marrow transplantation
1.1.4.3. Radiation
1.1.4.4. Monoclonal antibodies
2. Hodgkins Lymphoma (HL)
2.1. Pathophysiology: Enlarged, malignant B cells called RS cells that may contain EBV
2.1.1. Signs & symptoms
2.1.1.1. Sore throat
2.1.1.2. Fever
2.1.1.3. Trouble swallowing
2.1.1.4. Shortness of breath
2.1.1.5. Abdominal pain
2.1.2. Physical Assessment Findings
2.1.2.1. Painless enlarged lymph node
2.1.2.2. Pharyngeal edema & erythema
2.1.2.3. Signs of infection
2.1.2.4. Splenomegaly
2.1.2.5. Enlarged thymus
2.1.3. Diagnostic Testing
2.1.3.1. Pharyngeal CBC with differential
2.1.3.2. Flow cytometry
2.1.3.3. Serum chemistry
2.1.3.4. CT of abdomen, thorax or pelvis
2.1.3.5. PET scan
2.1.3.6. Lymph node biopsy
2.1.3.7. Bone marrow aspirate
2.1.3.8. Excessive WBC's in CBC & bone marrow
2.1.3.9. Biopsy shows RS cells
2.1.4. Treatment
2.1.4.1. Combination chemotherapy
2.1.4.2. Bone marrow stem cell transplantation
2.1.4.3. Immunotherapy (monoclonal antibodies)
2.1.4.4. Radiation