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Blood Coagulation by Mind Map: Blood Coagulation
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Blood Coagulation

By: Mohammed Hamza Haneef

Definitions

coagulation

The process of forming blood clots

fibrinolysis

A process by which the clot is dissolved

thrombosis

blood clots that causes obstruction of a vessel; pathologic formation of thrombus

DVT

Deep venous thrombosis- causes pulmonary embolism

embolus

a broken piece of a thrombus

arterial thromboembolism

obstruct blood flow in coronary or cerebral arteries

Causes of thrombosis

atherosclerosis

plaque rupture initiantes platelet adhesion causing thrombosis

cancer

Tumors secrete cysteine protease which activates factor X of coagulation

high homocysteine levels

Caused by deficiency of folic acid, vitamin B6 and B12

estrogen containing contraceptives

Women of blood groups A,B, and AB are at high risk

infection

like sepsisIncreased risk of venous thrombosis

stasis

Immobilization of bodily fluids due to many reasons (surgery, paralysis, heart failure, obesity, pregnecy.. etc)

anticoagulants

Drugs that reduce clotting ability of the blood

heparin

LMWHs

fondaparinux

warfarin

antiplatlet

inhibit platelet aggregationexample: aspirin

prostaglandin synthesis inhibitors

Example: aspirin

phosphodiesterase inhibitor

inhibiting the enzyme phosphodiesterase, so cellular levels of cAMP are decreased- Example: Dipyridamole

ADP antagonists

antagonists of ADP on P2Y12 and prevent platelet aggregation - example: ticlopidine and clopidogrel

glycoprotein receptor antagonist

Example: abciximab

thrombolytic (fibrinolytic) agents

dissolves the fibrin mesh

mechanism

adverse effects

examples