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Aminoglycosides by Mind Map: Aminoglycosides
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Aminoglycosides

Derived from Streptomyces

streptomycin

kanamycin

tobaramycin

neomycin

paromomycin

Derived from Micromanosporum

astromycin

gentamicin

sisomicin

Semi synthetic

arbekacin

netlimicin

amikacin

Mechanism

irreversible inhibition of protein synthesis

Pharmacokinetics

highly polar

poorly absorbed from the GI unless diseased

rapidly absorbed IM

usually given IV

excreted by kidney

concentration dependent effect

usually used in combination with beta lactum or glycopeptide

adverse effects

Indications

resistant UTI

hospital acquired pneumonia

combined with BL

resistant meningitis

bacterial endocarditis

granulocytopenia and sepsis

nosocomial infections