The endocrine system 2

1. Red clover

1.1. ➢Constituents: • The major actives are the isoflavones: ➢ Genistein, ➢ Afrormosin, ➢ Biochanin,A

1.1.1. Therapeutic uses:natural method of 1-hormone replacement therapy 2-treating hot flushes in menopausal women

1.1.2. Side effect: • Red clover is considered safe

1.1.2.1. Herb drug interaction (1): • Agents metabolized via cytochrome P450 3A4. • Anticoagulant/antiplatelet agents, nonsteroidal anti-inflammatory drugs (NSAIDS). • Hormone replacement therapy (HRT), oral contraceptives (OCPs)

1.1.2.1.1. Contraindication: • Avoid use in patients with/at risk for breast cancer/estrogen receptor-positive neoplasia/endometrial hyperplasia.

2. soya

2.1. ➢Chemical constituents: • Soybean contains phytoestrogens of two chemical types: ➢ Isoflavones including genistein and their derivatives, ononin and others. ➢ coumestans such as coumestrol