1. Introducción
1.1. skin disease
1.1.1. demarcated erythematosquamous plaques
1.1.1.1. restricted to
1.1.1.1.1. distintic sites
1.1.1.1.2. disseminated
1.2. types
1.2.1. psoriatic arthritis
1.2.2. comorbidity
1.3. Metabolis cyndrome
1.3.1. cardiovascular diseases
1.3.2. depressions
1.4. suggested->autoimmunity
1.4.1. associated with others
1.5. TLR?
2. Clinical aspects
2.1. Common
2.1.1. 2.5% in Caucasian
2.2. 80%
2.2.1. Circumscribed
2.2.2. Disseminated
2.3. 20%
2.3.1. plaque psoriasis
2.3.1.1. 20%
2.3.1.1.1. sterile pustules
2.4. Symptoms
2.4.1. Itch
2.4.2. Pain
2.4.3. musculosceletal manifestations
2.4.3.1. spondylarthritis
2.4.3.2. enthesitis
2.4.3.3. dactylitis
2.5. Risk Factors
2.5.1. Not defined
3. Phatogenic
3.1. Histological traits
3.1.1. Acanthosis
3.1.2. Hyperkeratosis
3.1.3. lymphohistiocytic inflammation
3.1.4. elongation of dermal capillary vessels
3.2. Major traits
3.2.1. Allocated to heterogenous immuno genetic background
3.2.2. Enviromental
3.2.3. Endogenous
3.3. Cellular & Citokyne imbalance
3.3.1. T-Lymphocytes
3.3.1.1. Major cellular player
3.3.1.2. Activated by TNF a
3.3.1.3. Interleukins 23 & 17
3.4. antigen-specific autoimmune pathogenesis has so far been only speculated on
4. Clinical
4.1. Associated with other autoimmune dis.
4.1.1. autoimmune thyroid diseases like Hashimoto's and Graves' disease
4.1.2. Crohn's disease, diabetes mellitus, vitiligo
4.1.3. alopecia areata celiac disease and rarely systemic lupus
4.1.4. erythematosus
4.2. Cellular & humoral immunoreactivity
4.3. Orgna involment
4.4. Autoantibodies have been studied
4.4.1. anti-BP180 antibodies
4.4.2. anti-gliadin
4.4.3. anti-transglutaminase
4.5. lupus erythematosus (LE)-like symptoms in a small subset of TNF-blocker treated patients
5. Autoinmminuty
5.1. 5- possible autoantigens
5.1.1. T-cell targets
5.1.1.1. Type 1 keratins
5.1.1.1.1. homologies with Streptoccocal M pp
5.1.1.2. Human papiloma virus 5
5.1.1.3. ADAMTS-like pp 5
5.1.2. Serological targets
5.1.2.1. Type 1 keratins
5.1.2.2. ADAMTS-like protein 5 Collagen XVII
5.1.2.3. Gliadin
5.1.2.4. Squamous cell carcinoma antigen
5.1.2.5. Heat shock proteins
5.1.3. Induction or exacerbation
5.1.3.1. streptococcal infection
5.2. 6. Innate immunity & autoinflamation
5.2.1. dysregulation of the antibiotic peptide LL37
5.2.1.1. which is involved in DNA protection was shown
5.2.2. Mechanical and microbiological injury
5.2.2.1. complexed by LL37 and endocytosed via TLR9 by plasmacytoid cells resulting in the production of interferons
5.2.3. Inflammatory processses
5.2.3.1. Make self Ag accesible
5.2.3.2. Diruot immune tolerance
5.2.3.3. Activate autoreactive cells