-sec by chondrycytes -requires special elastic stain to visulize fibers (looks like hyaline cartilage in H&E stain) -random orientation of fibers
**whats the predominant fiber in elastic cartilage???**** -ground substance to fiber ratio
Cells (1 predom)
EC fibers (2), elastic fibers, Col II
resilient force & lots of flexibility
dx char: presence of elastic fibers NOTE: in H&E stain it looks just like hyaline chartilage but look for the presenence of elastic fibers be able to identify: -perichondrium (see hyaline cartilage --> EC fibers ---> perichondrium) -chondrogenic layer -isogenic cells (see hyaline cartilage --> cells --> chondroblasts --> isogenic group)
H&E stain: how can you the difference bet elastic and hyaline cartilage???
Hyaline Cartilage: -lrg, round, randomly scattered cells separated by lots of ECM (Dx of all cartilage) -avascular (Dx of hyaline cartilage) -surrounded by perichondrium (dense irreg CT), except at articular end of bone
costal cartilage, costal cartilage
trachea, bronchi of lungs
larynx, nasal cartilage
articular cartilage in synovial joints, NO perichondrium surrounding it, articular cartilage in synovial joints
-what is the ground substance to fiber ratio?
Cells (2), Chondrocytes, Chondrocytes pic, lacunae, Chondroblasts, Chondroblasts: isogenic/nest groups, interstitial growth
Ground Substance, Types of matrix (2), territorial/capsular matrix, territorial/capsular matrix pic, interterritorial matrix, Proteoglycans, proteoglycan subunit, aggrecan, proteoglycan aggregates, functions (3), Glycoproteins (2), Chondronectin, Chondronectin pic, Chondrocalcin, Chondrocalcin pic
EC Fibers, Col II, pericellular capsule
1- mesenchymal cells condense to form pro cartilage2- chrondroblasts sec matrix3- cartilage formation (induced by low O2 levels when far from bv source)4-now is chondrocyte
Development of Cartilage
what are the dx characteristic of cartilage?? what are the dx characteristic of hyaline cartilage?? be able to pick out : perichondrium (dense irregular CT that surrounds) *chondrogenic layer **** DOES CHONDROGENIC LAYER = PERICHONDRIUM???? *interterritoral and territorial layer *chondroblasts vs. chondrocytes
chondrocyte vs. chondroblasts & perichondrium
-lrg & round shape = dx characteristic -not much ground substance bc so much collagen fibers-always associated w/ dense CT ***make sure you can tell the difference bet fibrocartilage and dense reg CT like in tendons****
-lots of fibers running in diff directions how do you know this is not dense irreg CT??
fibrocartilage has lrg, round cells
*what is the predom fiber?*what is it sec by??*ground substance to fiber ratio
densely packed COL I
scant ground sub
intervertebral discs (2), annulus fibrosis, nucleus pulposis, Herniated Disc
attachment bet tendon & bone, Fibrocartilage between tendon and bone
cushion / abs impact
tough, resistant but not rigid
lots of 'give'
Functional (3), Synarthroses, Amphiarthroses, Diarthroses, pneomic, SAD Arthur giving roses
Structural (3), Fibrous (3), Sutures, midsaggital suture, Syndesmoses, interosseous ligament, Gomphoses, Periodontal ligament, Cartilagenous (2), Synchrondoses, Epiphyseal plates, Costal Cartilage, Symphyses, pubic symphysis, intervertebral disc, Synovial, Parts of Synovial Joint (5), synovial cavity, articular cartilage, function, Structure: Zones/Layers (3), Surface cartilage, calcified cartilage layer, subchondral bone, articular cartilage zones, articular capsule, synovial membrane, synovial fluid (3), Synovial Joint pic, Types of Synovial Joints (6), Gliding, interphangeal joints, Hinge, elbow joint, Pivot, proximal radial ulnar, atlantoaxial joints, Ellipsoid, radiocarpal joints, saddle, carpal-metacarpal joint of thumb, Ball&socket, shoulder & hip joints
-difficult bc limited nut support to joint-fractured joint does NOT undergo mitosis
chondroprogenitor cells, punch hold from subchondral bone
continuous movement, stimules cartilage formation
repair tissue = fibrocartilage
Osteoarthritis, noninflammatory progressive degeneration, affects synovial joints, fibrillation of articular cartilage, proliferation of cartilage at periphery, replacement of cartilage spur with bone tissue
Rheumatoid Arthritis, inflammatory autoimmune, thickened synovial membrane, pannus of tissue erodes away cartilage, bone fuses across joint
any joints in lab???