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2: How drugs work by Mind Map: 2: How drugs work
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2: How drugs work

why do drugs work?

Langley and Ehrlich's receptor hypothesis

Fischer's Lock and Key hypothesis

Koshland's "induced fit" hypothesis

initial binding

change in receptor or drug structure

receptor is flexible

Drug target classes

receptors

A cellular macromolecule that a drug binds to, to produce a response most are proteinscan be membrane bound or intracellular example: salbutamol --> B2 receptor

G-protien coupled receptors

Tyrosine-Kinase coupled receptors

Steroid hormone receptors

enzymes

complex proteins that regulates the rate of biochemical reactions within cells example: ACE inhibitors

ion channels

trans-membrane pore-forming proteins to regulate the flow of ions across the cell membrane

voltage gated

ligand gated

transport (membrane) proteins

involved in movement of ions, small molecules or macromolecules across a biological membrane 

facilitated diffusion

active transport

Factors governing drug action

affinity

how tight is the bond with the receptor

intrinsic activity

the ability of the drug to produce and effect

Modes of drug-receptor interaction

agonist

binds to receptor and simulate

have both affinity and intrinsic activity

types, full agonist, partian agonist

antagonist

only affinity, no intrinsic activity

bind to receptor but no response

types, competitive antagonist, non-competitive / irreversible antagonist

Inverse antagonist

eliminates constitutive receptor activity

has affinity and negative intrinsic activity

example: propranolol (beta receptor antagonist)

Recombinant proteins

derived from DNA recombinant technology. clean but expensive modify and repair genetic errors, destroy cancer cells, treat immune disorders .. etc examples:ErythropoietinG-CSFinsuline for diabetes