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2: How drugs work by Mind Map: 2: How drugs work
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2: How drugs work

why do drugs work?

Langley and Ehrlich's receptor hypothesis

Fischer's Lock and Key hypothesis

Koshland's "induced fit" hypothesis

Drug target classes

receptors

A cellular macromolecule that a drug binds to, to produce a response most are proteinscan be membrane bound or intracellular example: salbutamol --> B2 receptor

enzymes

complex proteins that regulates the rate of biochemical reactions within cells example: ACE inhibitors

ion channels

trans-membrane pore-forming proteins to regulate the flow of ions across the cell membrane

transport (membrane) proteins

involved in movement of ions, small molecules or macromolecules across a biological membrane 

Factors governing drug action

affinity

how tight is the bond with the receptor

intrinsic activity

the ability of the drug to produce and effect

Modes of drug-receptor interaction

agonist

antagonist

Inverse antagonist

Recombinant proteins

derived from DNA recombinant technology. clean but expensive modify and repair genetic errors, destroy cancer cells, treat immune disorders .. etc examples:ErythropoietinG-CSFinsuline for diabetes