anticoag: Direct thrombin inhibitors
by Anneke Klomp
1. dabigatron
1.1. prevention of stroke and blood clots in pts w/ afib; prevention//tx of VTE
1.2. fast onset
1.3. AE: bleeding
2. praxbind
2.1. reversal agent for dabigatron (pradaxa)
2.1.1. if life threanening bleeding
2.2. ae: constipation, nausea, watch for thrombosis and restart anticoag ASAP
3. direct acting anticoags: first line for anticoags
3.1. apixaban; dabigatron; rivaroxaban; edoxaban
4. MOA: binds to and inactivate circulating and clot bound thrombin
5. agratroban; bivalirudin
5.1. for management of HIT; unstable angina undergoing PCTA
5.2. AE: bleeding - limits therapeutic use