Antihypertensives: ANG II receptor blockers (ARBs)
by Anneke Klomp
1. telmisartan
2. olmesartan
3. END IN -ARTAN
4. MOA: block ANG II receptor (AT) so action of ANG II is inhibited
4.1. no effects on bradykinin metabolism (bc they don't effect ACE)
5. indications: HTN; all pts post MI and HF; diabetic and non-diabetic proteinuria; reduce progression to clinical nephropathy
6. First line HTN drugs
7. losartan
8. valsartan
9. candesartan
10. irebesartan
11. AE: less cough; less angioedema; good for pts who cannot tolerate ACEI; may reduce progression fo Type 2 diabetic neuropathy; same pregnancy contraindication
11.1. same contraindicaton of b/l renal artery stenosis