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Hypersensitivity by Mind Map: Hypersensitivity
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Hypersensitivity

Type IV (delayed type)

dendritic cells activate Th1 cells which release INF gamma and TNF

these cytokines activates macrophages to form granuloma and causes tissue distraction and necrosis

examples

Type III (toxic complexes)

angry neutrophils disease

Mechanism

diagnosis

Type II (cytotoxic)

Most autoimmune diseases

the antibodies get attached to normal cells and they get killed CD8 doesn't play a role because it doesn't have Fc receptor or MHC-II

Mechanism

Symptoms

Diagnosis

Type I (immediate or anaphylactic)

Mechanism

Symptoms

Tests and diagnosis

Definitions

Undesirable immune response to specific antigen

They require pre-sensitization

Genetics play a role