Coagulation disorder

1. side effects: ▪︎ Bleeding ▪︎lack of platelets ▪︎ Increase potassium ▪︎ osteoporosis

1.1. Action: It interferes with the formation of fibrin inhibits the synthesis of thrombin from prothrombin.

1.1.1. Uses: (The most commonly used drug.) 1.Treatment of a blood clot destined for the lungs. 2.Prevention of intravenous thrombosis. 3_blood thinner. 4.Anticoagulant in blood transfusion

2. 1_Heparin:

2.1. Contraindications: ▪︎ Severe hypertension ▪︎ stroke ▪︎ liver disease

3. • Contraindications: •  Recent head injury • Brain aneurysm high blood pressure • Physical trauma

4. pharmaceutical : IV

5. Uses: 1. Treatment of heart attacks 2. Stroke 3. Prevention

6. 1_ Anticoagulant medications:

6.1. Action :To prevent thrombus formation (clot does not dissolve)

7. 2- antiplatelet drug :

7.1. Action: ▪︎Inhibit platelet aggregation ▪︎ inhibit clot formin.

8. 3_ Thrombolytics :

8.1. Action :We break and dissolve the clot

8.1.1. USED: ▪︎ Heart attacks ▪︎ Stroke ▪︎ Pulmonary embolism (PE) ▪︎ Deep vein thrombosis (DVT)

8.2. streptokinase 250000 IU 1 vial×6ml

9. pharmaceutical:Iv , S.C (P.s: pregnancy) Longer duration , Expensive Antidote: protamine sulfate

9.1. heparin 5000 IU/ML Laboratories: 50 vials x 5ml

9.1.1. heparin sodium 25,000 IU / ML Process: 10 vials x 5 ml

9.2. • Side effects:  Low blood pressure • Swelling • BleedingChest pain • Changes in heart rhythm

10. Contraindications: ▪︎Bleeding ▪︎ Alcoholism ▪︎ Hypertension ▪︎ pregnancy ▪︎Diseases of the liver ، kidneys ▪︎ drug interactions ▪︎ peptic ulcer

11. 2_Coumarin group: (Warfarin) .

11.1. Action: Preventing the formation of vitamin K-dependent clotting factors.

11.2. Uses: ▪︎Post-Myocardial Infarction ▪︎Cardiac Valve Replacement ▪︎Stroke and Thromboembolism ▪︎Venous Thrombosis

11.3. Side effects: ▪︎ Hemorrhage ▪︎ Rash ▪︎ anemia ▪︎ Elevated liver enzymes ▪︎ jaundice ▪︎fever

11.3.1. pharmaceutical:tab(Orally)It starts to take effect after 72 Antidote : Vitamin K (Iv)

11.3.1.1. Orfarin 5mg , 3mg