Sepsis

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Sepsis by Mind Map: Sepsis

1. Ultimate goal

1.1. Supportive Treatments until crisis or homeostasis can be reacheived

2. Infectious agent exposure

2.1. Initial Response

2.1.1. Pyrogenesis ( Fever)

2.1.1.1. Cytokine release

2.1.1.1.1. Interleukin 1

2.1.1.1.2. Neutrophils

2.1.1.1.3. Macrophages

2.1.1.2. Increased Sedimentation Rate

3. Systems Affected

3.1. Cardiovascular

3.1.1. Complement

3.1.2. Coagulation

3.1.3. Kallikein/ kinin

3.2. Respiratory

3.2.1. Acute Respiratory distress syndrome (ARDS)

3.2.2. Tachypnea

3.2.3. Pulmonary edema

3.2.4. Increased workload for respiration due to use of accessory muscles and hypoxemia

4. Diagnosis and Treatment

4.1. Fluid Resuscitation

4.1.1. Colloids and Crystalloid infusions

4.2. Respiratory Support

4.2.1. Oxygen administration

4.2.2. Artificial Respiration

4.3. Medications

4.3.1. Antibiotics

4.3.2. Antithrombolytics

4.3.3. Antiprosteglandins/ Antipyretics

4.3.4. Vasopressors

4.3.4.1. Ca Channel blockers

4.3.4.2. Dopamine

4.3.4.3. Norepinephrine

5. Groups affected

5.1. Gender

5.2. Age

6. Adaptive Response to infection

6.1. Recognition of Antigen

6.1.1. Dependencies

6.1.2. Milestones

6.2. Antibody Release

6.2.1. IGg

6.2.2. Histamines

6.2.3. Kinins

6.2.4. Complement

6.2.5. Prosteglandins

6.3. Clonal Response

6.3.1. T-Cells

6.3.2. B-Cells