CRE in Companion Animals
by Stephen Cole
1. IncK2
2. Location
2.1. North America
2.2. South America
2.3. Europe
2.4. Asia
2.5. Africa
2.6. Australia
3. Negative Studies
4. Survey of Carbapenemase-Producing Enterobacteriaceae in Companion Dogs in Madrid, Spain (González-Torralba et al., 2016)
5. Enterobacter cloacae Complex Sequence Type 171 Isolates Expressing KPC-4 Carbapenemase Recovered from Canine Patients in Ohio. (Daniels et al., 2018)
6. Plasmids
6.1. IncX3
6.2. IncFIB
6.3. IncHI2
6.4. IncI1-type
6.5. IncFII-type
6.6. IncL
6.7. IncF
6.8. IncL/M-1 type
6.9. IncA/C
6.10. IncI
6.11. IncN
7. Human Involvement
8. Detection of IncN-pST15 One-Health plasmid harboring blaKPC-2 in a hypermucoviscous Klebsiella pneumoniae CG258 isolated from an infected dog, Brazil (Sellera et al., 2021)
9. Emergence of OXA-48 carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in dogs. (Stolle et al., 2013)
10. Molecular Characteristics of NDM-5-Producing Escherichia coli from a Cat and a Dog in South Korea. (Hong et al., 2020)
11. Pathogenic Escherichia coli in Dogs Reveals the Predominance of ST372 and the Human-Associated ST73 Extra-Intestinal Lineages (Valat et al., 2020)
12. Clonal dissemination of OXA-48-producing Enterobacter cloacae isolates from companion animals in Algeria. (Yousfi et al., 2018)
13. Occurrence and characterization of Escherichia coli ST410 co-harbouring blaNDM-5, blaCMY-42 and blaTEM-190 in a dog from the UK (Reynolds et al., 2019)
14. Complete Genome Sequence of a Carbapenem-Resistant Escherichia coli Isolate with blaNDM-5 from a Dog in the United States (Tyson et al., 2019)
15. Distribution and antimicrobial resistance profiles of bacterial species in stray cats, hospital-admitted cats, and veterinary staff in South Korea. (Jung et al., 2020)
16. Additional Resistance
16.1. Colistin
16.2. Sulfonamide
16.3. Fosfomycin
16.4. Aminoglycoside
16.5. Tetracycline
16.6. Quinolone
16.7. Beta-Lactam
16.8. Trimethoprim
16.9. Chloramphenicol
16.10. Macrolide
17. Emergence of a New Delhi metallo-β-lactamase (NDM-1)-encoding gene in clinical Escherichia coli isolates recovered from companion animals in the United States (Shaheen et al., 2013)
18. Antimicrobial susceptibility of bacterial isolates from urinary tract infections in companion animals in Spain. (Darwich et al., 2021)
19. Risk Factors for the Acquisition of a blaNDM-5 Carbapenem-Resistant Escherichia coli in a Veterinary Hospital. (Lavigne et al., 2021)
20. Household transmission of carbapenemase-producing Enterobacteriaceae: a prospective cohort study (Marimuthu et al., 2021)
21. Prevalence of antimicrobial resistance and resistance genes in faecal Escherichia coli isolates recovered from healthy pets (Costa et al., 2008)
22. Beta-Lactamases in Ampicillin-Resistant Escherichia coli Isolates from Foods, Humans, and Healthy Animals (Briñas et al., 2002)
23. Poor infection prevention and control standards are associated with environmental contamination with carbapenemase-producing Enterobacterales and other multidrug-resistant bacteria in Swiss companion animal clinics. (Schmidt et al., 2020)
24. Genomic features of a polymyxin-resistant Klebsiella pneumoniae ST491 isolate co-harbouring blaCTX-M-8 and qnrE1 genes from a hospitalised cat in Sao Paulo, Brazil. (Sartori et al., 2020)
25. Antimicrobial‐resistant Enterobacteriaceae recovered from companion animal and livestock environments (Adams et al., 2018)
26. IncH-type plasmid harboring bla CTX-M-15, bla DHA-1, and qnrB4 genes recovered from animal isolates. (Schluter et al, 2014)
27. Carbapenemase IncF-borne blaNDM-5 gene in the E. coli ST167 high-risk clone from canine clinical infection, Italy. (Alba et al., 2021)
28. Assess acquisition, prevalence of and risk factors for MDRO carriage in dogs and cats presented to veterinary clinics or practices in Switzerland. (Dazio et al., 2021)
29. The occurrence of Salmonella, extended-spectrum β-lactamase producing Escherichia coli and carbapenem resistant non-fermenting Gram-negative bacteria in a backyard poultry flock environment (Shah et al., 2020)
30. Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae Isolated from healthy and sick dogs in Portugal. (Carvalho et al., 2020)
31. Shedding of OXA-181 carbapenemase-producing Escherichia coli from companion animals after hospitalisation in Switzerland: an outbreak in 2018 (Nigg et al., 2019)
32. Colistin Susceptibility in Companion Animal-Derived Escherichia coli, Klebsiella spp., and Enterobacter spp. in Japan: Frequent Isolation of Colistin-Resistant Enterobacter cloacae Complex (Sato et al., 2022)
33. Enterobacterales high-risk clones and plasmids spreading blaESBL/AmpC and blaOXA-48 genes within and between hospitalized dogs and their environment (Haenni et al., 2022)
34. Prevalence, incidence and risk factors for acquisition and colonization of extended-spectrum beta-lactamase- and carbapenemase-producing Enterobacteriaceae from dogs attended at a veterinary hospital in Spain. (Ortiz-Diez et al., 2022)
35. Species Tested
35.1. Dogs
35.1.1. Found Positive
35.1.2. All Negative
35.2. Cats
35.2.1. Found Positive
35.2.2. All Negative
35.3. Other Companion Animals
35.3.1. Found Positive
35.3.2. All Negative
36. Carbapenemase Gene
36.1. NDM
36.2. OXA-48
36.3. VIM
36.4. KPC
36.5. OXA-181
37. Study Design
37.1. Active surveillance
37.2. Passive surveillance
37.3. Case Report/Case Series
38. Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals. (Li et al., 2019)
39. First Detection of New Delhi Metallo-beta-Lactamase-5-Producing Escherichia coli from Companion Animals in Korea. (Hong et al., 2019)
40. Multiresistant extended-spectrum β-lactamase-producing Enterobacteriaceae from humans, companion animals and horses in central Hesse, Germany. (Schmiedel et al., 2014)
41. Characterization of ESBL-and AmpC-producing Enterobacteriaceae from diseased companion animals in Europe (Bogaerts et al., 2015
42. Emergence of Carbapenemase-Producing Escherichia coli Isolated from Companion Animals in Algeria (Yousfi et al., 2016)
43. Extended spectrum β-lactamase and plasmid mediated quinolone resistance in Escherichia coli fecal isolates from healthy companion animals in Algeria.(Yousfi et al., 2016)
44. Host-Specific Patterns of Genetic Diversity among IncI1-Igamma and IncK Plasmids Encoding CMY-2 beta-Lactamase in Escherichia coli Isolates from Humans, Poultry Meat, Poultry, and Dogs in Denmark (Hansen et al., 2016）
45. Antimicrobial resistance profiles and genotypes of extended-spectrum β-lactamase-and AmpC β-lactamase-producing Klebsiella pneumoniae isolated from dogs in Beijing, China. (Liu et al., 2017)
46. In vitro efficacy of 16 antimicrobial drugs against a large collection of β-lactamase-producing isolates of extraintestinal pathogenic Escherichia coli from dogs and cats. (Shimizu et al., 2017)
47. Antimicrobial resistance in clinical Escherichia coli isolated from companion animals in Australia. (Saputra et al., 2017)
48. Occurrence of OXA-48 Carbapenemase and Other β-Lactamase Genes in ESBL-Producing Multidrug Resistant Escherichia coli from Dogs and Cats in the United States, 2009–2013. (Liu et al., 2016)
49. New Delhi Metallo-β-Lactamase-5–Producing Escherichia coli in Companion Animals, United States (Cole et al., 2020)
49.1. Sharing more than friendship - transmission of NDM-5 ST167 and CTX-M-9 ST69 Escherichia coli between dogs and humans in a family, Finland, 2015. (Grönthal et al., 2018)
50. OXA-48-producing ST372 Escherichia coli in a French dog. (Melo et al., 2016)
51. Isolation and plasmid characterization of carbapenemase (IMP-4) producing Salmonella enterica Typhimurium from cats (Abraham et al., 2016)
52. Companion Animals Emerged as an Important Reservoir of Carbapenem-Resistant Enterobacteriaceae: A Report from India (Bandyopadhyay, 2021)
53. Multispecies and Clonal Dissemination of OXA-48 Carbapenemase in Enterobacteriaceae From Companion Animals in Germany, 2009-2016 (Pulss et al., 2018)
54. Emergence of blaNDM-5 in Enterobacteriaceae Isolates from Companion Animals in Guangzhou, China. (Wang et al., 2020)
55. Circulation of emerging NDM‐5‐producing Escherichia coli among humans and dogs in Egypt. (Ramadan et al., 2020)
56. OXA-181-Producing Extraintestinal Pathogenic Escherichia coli Sequence Type 410 Isolated from a Dog in Portugal. (Brilhante et al., 2020)
57. The Public Health Burden of Virulent Extended-Spectrum beta-Lactamase-Producing Klebsiella pneumoniae Strains Isolated from Diseased Horses. (Samir et al., 2022)
58. Characterization of 2 Klebsiella pneumoniae carbapenemase–producing Enterobacterales isolated from canine rectal swabs. (Cole et al., 2021)
59. Comparative genomic analysis of plasmids encoding metallo-β-lactamase NDM-5 in Enterobacterales Korean isolates from companion dogs (Kyung et al., 2022)
60. Colonization dynamics of Klebsiella pneumoniae in the pet animals and human owners in a single household. (Chen et al., 2021)
61. Risk factors associated with faecal carriage of extended-spectrum cephalosporin-resistant Escherichia coli among dogs in Southeast Brazil. (Salgado-Caxito et al., 2021)
62. Two high-risk clones of carbapenemase-producing Klebsiella pneumoniae that cause infections in pets and are present in the environment of a veterinary referral hospital. (Brilhante et al, 2021)
63. Employees of Swiss veterinary clinics colonized with epidemic clones of carbapenemase-producing Escherichia coli. (Endimiani et al., 2020)
64. Multidrug-resistant Escherichia coli isolated from canine faeces in a public park in Quito, Ecuador (Ortega-Paredes et al., 2019)
65. First report of a blaNDM-5-harbouring Escherichia coli ST167 isolated from a wound infection in a dog in Switzerland. (Peterhans et al., 2018)
66. β-lactam and fluoroquinolone-resistant enterobacteriaceae recovered from the environment of human and veterinary tertiary care hospitals. (Mathys et al., 2018)
67. Environmental testing
68. blaNDM-1-producing multidrug-resistant Escherichia coli isolated from a companion dog in China (Cui et al., 2018)
69. Multidrug-Resistant Klebsiella pneumoniae Complex From Clinical Dogs and Cats in China: Molecular Characteristics, Phylogroups, and Hypervirulence-Associated Determinants (Zhang et al., 2022)
70. Massive Spread of OXA-48 Carbapenemase-Producing Enterobacteriaceae in the Environment of a Swiss Companion Animal Clinic. (Schmitt et al., 2022)
71. NDM-5-Producing Escherichia coli Co-Harboring mcr-1 Gene in Companion Animals in China. (Kuang et al., 2022)
72. First Belgian Report of Ertapenem Resistance in an ST11 Klebsiella Pneumoniae Strain Isolated from a Dog Carrying blaSCO-1 and blaDHA-1 Combined with Permeability Defects (Debergh et al., 2022)
73. Bacterial Isolates from Urinary Tract Infection in Dogs and Cats in Portugal, and Their Antibiotic Susceptibility Pattern: A Retrospective Study of 5 Years (2017–2021) (Garces et al., 2022)
