Ovarian Tumors classification

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Ovarian Tumors classification by Mind Map: Ovarian Tumors classification

1. Metatatic Tumors to the ovary

1.1. Krukenberg tumors

1.1.1. Metastatic carcinoma

1.1.2. Signet ring cells

1.1.3. Sites of origin: Stomach Colon appendix

2. Sex Cord Tumors

2.1. Rare tumor

2.2. Often produce steroids hormones

2.3. Types:

2.3.1. Granulosa cell tumor Uni-lateral solid and cyst Hormonally active tumor MOST COMMON Estrogenic ovarian neoplasm. can be associated with endometrial hyperplasia & carcinoma why? bcoz it produce estrogen, and Enomertial hyperplasia & carcinoma are Estrogen responsive tumors !! Forms: Adult form Juvenile form Histologically: Call-Exner bodies

2.3.2. Thecoma-Fibroma Functional tumor = produce estrogen in post-menopausal women may develop endometrial hyperplasia and carcinoma. Morphology Gross M/E

2.3.3. Sertoli-Leydig cell tumor 1% of ovarian neoplasm predominantly in young woemn Androgenic so it cause defminization of women may cause virilization morphology: M/E:

3. Epithelial surface Tumors


3.2. derived from the cells on the surface of the ovary.

3.3. Most common primary neoplasm in ovary

3.4. 90% of malignant tumors of ovary

3.5. occur in adult

3.6. Types:

3.6.1. Serous (Tubal) Bilateral (30-66%) 75% Bengin/borderline, 25% malignant Tall columnar ciliated epithelium same as what we see in uterine tube Extension to peritonium = Bad prognosis Malignant serous tumors Commenst malignant ovarian tumor Partly cystic partly solid with necrosis & hemorrhage USUALLY present wth Ascites due to abdominal metastases ! also called: Serous cyst-adeno-carcinoma Morphology:

3.6.2. Mucinous Less common 25%, VERY LARGE Rarly malignant Rarly bilateral - 5-20% Tall columnar, apical mucin Pseudo-myxoma peritonei production of abundant mucin which fills the abdominal cavity, if untreated mucin may compresses vital organs e.g colon, liver, kidneys etc.. Types: Mucinous Cyst-adenoma-Borderline Mucinous Cyst-adeno-Carcinoma

3.6.3. Endometrioid Most are unilateral Cells look like endonetrium even though they are coming from the ovary. MOST OF THEM ARE malignant !! many are associated with endometrial cancer (30%) pt. may have concurrent endometriosis Endometrioid adeno-carcinoma: solid/cyst filled by hemorrhage & necrosis Stromal invasion by irregular malignant endometrial glands.

3.6.4. Transitional cell (Brenners)

3.7. Morphology

3.7.1. Cystic Cyst-adenomas

3.7.2. Solid/cystic Cyst-adeno-fibromas

3.7.3. Solid Adeno-fibroma

3.8. Behavior:

3.8.1. All types can be: Benign: Mostly cystic Borderline: Cystic/Solid foci Malignant: Mostly Solid

4. Germ cell tumors

4.1. occurs in children and teens

4.2. derived from the egg producing cells within the body of the ovary.

4.3. Rare tumor

4.4. Classification:

4.4.1. Germ cell No differentiation: Dysgerminoma differentiation Embryonal carcinoma Extra-Embryonic tissue: Embryonic tissue: