Streptococcus pneumoniae

1. Imunity

1.1. Competition between 2 serotypes

1.2. Acquired immunity

1.2.1. serotype-specific

1.2.2. Antibody-dependent

1.2.3. T-cell-dependent

1.2.3.1. Antibody-independent

1.3. vaccination-dep

1.3.1. Polysaccharide vaccine

1.3.1.1. Bcell-dependent reaction

1.3.1.2. protects against bacteraemia

1.3.1.3. does not protect against pneumococcal infection (colonization)

1.3.2. indirect effect

1.3.2.1. associated serotypes

2. Staphilococcus aureus

2.1. pilus?

3. Recombination

3.1. capsular switching after vaccination!

4. Carriage

4.1. High Carriage

4.1.1. Higher Replacement Potential

5. Disease

6. Vaccination

6.1. Polysaccharide vaccine

6.1.1. not efficient in young children

6.1.1.1. immunitary system immaturity?

6.2. Conjugate vaccine

6.2.1. 19A pos-appocalyptic (PCV7) main cause of IPD

6.2.2. Included serotypes

6.2.2.1. (4, 6B, 9V, 14, 18C, 19F, and 23F)

6.2.3. vaccine-related serotypes

6.2.3.1. vaccine-related serotypes

6.2.3.1.1. 6A

6.2.3.1.2. 9A,L,N

6.2.3.1.3. 18A,B,F

6.2.3.1.4. 19A,B,C

6.2.3.1.5. 23A,B