introduction to pharmacology

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introduction to pharmacology by Mind Map: introduction to pharmacology

1. key terms

1.1. mitigation

1.2. adsorption

1.3. Efficacy

1.4. Potency

1.5. Therapeutic index

1.6. Effective dose ED50

1.7. Lethal dose LD50

1.8. plasma half life

1.9. elimination half life

1.10. Steady-state concentration

2. classification

2.1. organ system

2.1.1. neuropharmacology

2.1.2. cardiovascular pharmacology

2.1.3. renal

2.1.4. pulmonary

2.2. techniques used

2.2.1. molecular

2.2.2. biochemical

2.2.3. immuno

2.2.4. behavioral

2.3. purpose of application

2.3.1. clinical

2.3.2. toxicolog

2.3.3. genetics

2.3.4. agricultural

3. Divisions

3.1. Toxicology

3.1.1. concepts toxic substance toxin Paracelsus concept drugs may have toxic side effects management concept groups at highest risk children1-3 years adolescence common between the two groups

3.1.2. reversibility depends on capacity of the tissue to regenerate examples liver CNS

3.1.3. classification target organ cardio toxic hepatotoxic neurotoxic nephrotoxic use pesticides food additives solvents source animal plant type of effect carcinogenicity mutagenicity teratogenicity lethality extremely toxic highly toxic moderately toxic slightly toxic practically non toxic relatively hermless other physical state reactivity chemical structure

3.1.4. duration of toxicity acute sub-acute chronic

3.2. Pharmacoeconomics

3.3. Pharmacoepidemiology

3.4. Pharmacogenetics

3.5. Pharmacotherapy

3.5.1. using drugs to active a therapeutic objective Cure of infection Mitigation of pain or fever Prevention Supplementation General anesthesia

3.5.2. Rule of right right drug right patient right does right cost

3.5.3. SANE criteria Safety Affordability Need Efficacy Preferred drug

3.6. Pharmacogenomics

3.7. Pharmacodynamics

3.7.1. Action types of actions stimulation depression both inhibition replacement Cytotoxic Neutralization receptors generalized receptors specialized receptors Targets Molecular level Cellular level Tissuey level systemic level Affinity Efficacy classification of drugs agonist partial agonist inverse agonist antagonis

3.7.2. Effect

3.8. pharmacokinetics

3.8.1. absorbtion Routs of administration Enteral Parenteral involves passage through passive diffusion filtration active transport facilitated diffusion endocytosis factors affecting absorption physiological factors physiochemical factors Bioavailability None-intravenous administration intravenous Bioequivalence

3.8.2. distribution rate-determening factors cardiac output regional blood flow lipid solubility binding to plasma protein organs that receives most of the drug initially brain liver kidney binding to drug carriers Albumin alpha-1-acid glycoprotein binding affinity

3.8.3. elimination metabolism if the drug is metabolized, it may be excretion kidneys intestinal tract breast milk sweat lungs