Uncertainty

1. Scientific Uncertainty

1.1. Clinical

1.1.1. Mechanisms

1.1.2. Outcomes

1.2. Methodology

1.3. Model

1.3.1. Structure

1.3.2. Parameter

1.3.3. Cost

1.4. Statistics

1.5. Evidence Base

1.6. Generalizability

2. Structural Uncertainty

2.1. Adoption

2.2. Affordability

2.3. Future Structural Elements

3. Normative Uncertainty

3.1. Acceptability

3.2. Political

3.3. Values

4. Inherent Uncertainty